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Cognitive testing and symptom assessment

CM Caitlin E. Murphy
AW Adam K. Walker
MO Maryanne O’Donnell
CG Cherrie Galletly
AL Andrew R. Lloyd
DL Dennis Liu
CW Cynthia Shannon Weickert
TW Thomas W. Weickert
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As part of a battery of baseline psychometric assessments [27], all participants were administered cognitive subtests that measured PFC-dependent working memory (Letter-Number Sequencing [LNS] and Arithmetic from the Wechsler Adult Intelligence Scale-Third Edition [WAIS-III]) [29] and tests of language abilities (letter fluency from the Controlled Oral Word Association Test [COWAT] [30] and WAIS-III Similarities). Assessments were made by a psychologist or psychometrician trained in administration and scoring. The 2 working memory test scores were converted to z-scores and summed, and the 2 language test scores were converted to z-scores and summed, to provide separate overall scores for working memory and language respectively. Symptom severity was assessed in patients at baseline using the Positive and Negative Syndrome Scale (PANSS) [31].

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