Confirmatory testing

CCT: During the test, patients remained in the supine position, and PAC and PRA were measured at 0, 60, and 90 min after the oral administration of captopril (50 mg). The CCT was considered to be positive if the ARR at 60 or 90 min after captopril administration was >20.^4,5,9

SIT: Patients were administered an intravenous drip infusion of 2 l of 0.9% NaCl over 4 h. After infusion, PAC was measured. The SIT was considered to be positive if PAC>6.0 ng/dl.^4,5,9

FUT: After maintaining a supine position for at least 30 min, venipuncture was performed for the measurement of basal PRA. A bolus injection of 40 mg furosemide was administered to each patient. Patients maintained an upright posture during the test. At 2 h after furosemide administration, PRA was measured. The FUT was regarded as positive if PRA<2.0 ng/ml/h.^4,5,9