2.5. Interaction assessment between DElncRNAs, miRNA and DEmRNAs

To clearly understand the functions of DElncRNA and miRNA with DEmRNAs, we developed the network of DElncRNA-miRNA-DEmRNA interactions. RNAInter (RNA Interactome database) is a database that promotes the development of the Interactome and increases knowledge on the biological functions and molecular mechanisms of RNAs. We set categories on lncRNA, species on H. sapiens, interaction type on RNA-RNA interaction, detection method on computational prediction, and the interval of confidence score between 0.1 and 1. Using RNAInter, we identified the interactions between DElncRNAs and some DEmiRNAs that targeted DEmRNAs and had three or more binding sites on the nucleotide sequence of the SARS-CoV-2 genome. Also, the interactions between DEmRNAs, which were targeted by the mentioned DEmiRNAs and DElncRNAs, were implemented.

Finally, the lncRNA-miRNA-mRNA networks were constructed using the Cytoscape (2.7.2) software.