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Study size.

FR Fernando Rosso
LP Luis G. Parra-Lara
OA Olga L. Agudelo-Rojas
DM Diana M. Martinez-Ruiz
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The sample size was calculated to test the hypothesis that the median NLRs in COVID-19 patients is higher than that in dengue patients. For a confidence level of 95% and a power of 80%, the sample size was for each group24:

where

zα/m=−2.13 is the z value of the significance level adjusted by Bonferroni (m = 6 comparisons: Dengue versus COVID-19 stratified by intensive care unit [ICU], sex, age group, and interaction).

m1=4.7 is the median NLR in COVID-19 patients.25

φ1=4.68 is the standard deviation of NLR in COVID-19 patients.26

m2=0.90 is the median NLR in dengue patients (obtained from a previous dengue study published by our group.27

φ2=6.85 is the standard deviation of NLR in dengue patients (obtained from a previous dengue study published by our group.27

With this sample size, it was possible to identify increases greater than 3.8 in the NLR in COVID-19 patients compared with dengue patients. However, we decided to include all the cases found in the study period because we attempted to answer a question that has not been previously resolved in the literature.

Copyright and License information:  ©2021 The American Society of Tropical Medicine and Hygiene
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