Recombinant inbred lines

The RILs we analyzed here were from the BxD panel of RILs. RILs are generated by crossing two parental strains, breeding the progeny for some number of generations to produce recombinant chromosomes, and then inbreeding to generate stable, inbred genotypes. The result is a panel of inbred mice each with a unique combination of genotypes from the parental strains. BxD were generated from an initial cross between the C57Bl/6J (B) mouse and the DBA/2J (D) mouse. We downloaded data from the MousePhenomeDatabase (Grubb et al. 2014) on August 5, 2020.

The data we analyzed were from an experiment investigating the genetics of hippocampal anatomy and spatial learning (Delprato et al. 2015, 2017, 2018). The data set is called Crusio1. We downloaded all traits related to body weight, radial maze performance, and histopathology.

The BxD panel has been genotyped at 7124 markers across the genome. The genotypes are available from GeneNetwork (Sloan et al. 2016). We analyzed time to complete the radial maze on the first day of training (task_time_d1) and the number of radial arms entered on day 5 of training (num_arms_d5) in 452 females.