Information regarding the age, sex, ethnicity, body mass index (BMI), smoking, alcohol consumption, presence of comorbidities (systemic hypertension, diabetes, dyslipidaemia, history of coronary disease/stroke, tuberculosis and HIV infection) were collected in all enrolled subjects. Comorbidities were considered as binary variables (YES/NO) without further characterization6.
Clinical information and laboratory parameters of COVID-19 patients were also collected. A Complete list can be found in the first report of the study6.
Patients were classified as having severe COVID-19 if they had any of the following: hypoxia (oxygen saturation ≤ 93 percent on room air or PaO2/FiO2 < 300 mmHg), tachypnoea (respiratory rate > 30 breaths per minute) or respiratory distress, more than 50 percent involvement of the lung parenchyma on chest imaging6. The remaining patients were classified as non-severe13.
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