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Morris water maze (MWM) test

YZ Yang Zhou
HL Huanyu Lu
YL Ying Liu
ZZ Zaihua Zhao
QZ Qian Zhang
CX Chong Xue
YZ Yuankang Zou
ZC Zipeng Cao
WL Wenjing Luo
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Animals were trained in the hidden platform version of the MWM task as described in our publications [46].The hidden platform training was performed for 5 days straight (4 trials per mouse, per day). Each animal was placed in one of four chosen starting locations in the pool and had 60 s to locate the hidden platform. If an animal failed to find the platform, it was placed on top of it and had to remain there for 20 s before being put back into its cage by the experimenter. After 5 days of training, one probe trial was performed per mice and each mouse searched for 60 s. All trials were recorded via a digital camera connected to Enthovision ET software and DigiBehave system (Xinruan, China) which was used to record the animals’ behaviors.

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