iEPO administration

JL Jie Li
AA Ashley E. Augustynovich
PG Payal K. Gurnani
JF James B. Fink
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Per our institution protocol, iEPO was initiated at a dose of 50 ng/kg/min based on PBW and maintained for a minimum of 24 h after initiation. iEPO weaning was determined by the treating physician(s) and titrated down by 10 ng/kg/min every 30–60 min if the patient’s status remained stable [7]. In the high concentration group, iEPO dose was titrated by adjusting the pump rate. In the low concentration group, iEPO dose was titrated by adjusting the pump rate and iEPO concentrations. For example, if the dose was reduced from 40 to 30 ng/kg/min, the iEPO concentration was changed from 15 to 7.5 mcg/mL, in order to maintain pump rate between 8 and 20 mL/h.

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