Abstract
The induction of type I IFN is the immediate host response against viral infections. Type I IFNs belong to a multigene family including up to 14 different IFN-α subtypes and one IFN-β. They are highly conserved and bind the same receptor (IFNAR1/2) with varying affinities, although they differ in their biological activities.
Keywords: Type I IFNs, IFN-alpha subtypes, Mx expression
Materials and Reagents
Equipment
Procedure
Different murine IFN-α subtypes (IFN-α1, -α2, -α4, -α5, -α6, -α9, -α11) were produced as already described (Gerlach et al., 2009).
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Recipes
Acknowledgments
This work was supported by the Deutsche Forschungsgemeinschaft (GRK 1045).
References
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