Abstract
Glioma Associated Stem Cells (GASCs) represent a population of non-tumorigenic multipotent stem cells hosted in the microenvironment of human gliomas. In vitro, these cells are able, through the release of exosomes, to increase the biological aggressiveness of glioma-initiating cells. The clinical importance of this finding is supported by the strong prognostic value associated with the GASCs surface immunophenotype thus suggesting that this patient-based approach can provide a groundbreaking method to predict prognosis and to exploit novel strategies that target the tumor stroma (Bourkoula et al., 2014).
Keywords: Human glioma, Stem cells, Microenvironment, Tumor-supporting function
Materials and Reagents
Equipment
Procedure
Representative data
Recipes
Acknowledgments
FIRB Accordi di programma 2011 Pr. RBAP11Z4Z9. FIRB accordi di programma 2011 Pr. RBAP11ETKA_007. Programma per la Cooperazione Transfrontaliera Italia-Slovenia 2007-2013. Title: “Identificazione di nuovi marcatori di cellule staminali tumorali a scopo diagnostico e terapeutico”; AIRC 5 per mille Special program 2011, Pr. 12214. Project ERC- 7FP SP 2 IDEAS QUIDPROQUO G.A. n. 269051. The protocol was adopted from Bourkoula et al. (2014).
References
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