Jerry W. Shay
  • Department of Cell Biology, University of Texas Southwestern Medical Center, USA
研究方向
  • Cancer biology
个人信息

Current position

Vice Chairman, the Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas
Associate Director, the Harold Simmon's NCI Designated Comprehensive Cancer Center, and holds the Southland Corporation Distinguished Chair in Geriatrics Research
Distinguish Teaching Professor and Director of the Cancer Biology Graduate Program at UT Southwestern

Publications (since 2012)

  1. Zhang, L., Kim, S., Jia, G., Buhmeida, A., Dallol, A., Wright, W. E., Fornace, A. J., Al-Qahtani, M. and Shay, J. W. (2015). Exome Sequencing of Normal and Isogenic Transformed Human Colonic Epithelial Cells (HCECs) Reveals Novel Genes Potentially Involved in the Early Stages of Colorectal Tumorigenesis. BMC Genomics 16 Suppl 1: S8.
  2. Mender, I., Gryaznov, S., Dikmen, Z. G., Wright, W. E. and Shay, J. W. (2015). Induction of telomere dysfunction mediated by the telomerase substrate precursor 6-thio-2'-deoxyguanosine. Cancer Discov 5(1): 82-95.
  3. Pandita, R.J., Chow, T.T., Udayakumar, D., Bain, A.L., Cubeddu, L., Hunt, C.R., Shi, W., Horkoshi, N., Zhao, Y., Wright, W.E., Khanna, K.K, Shay, J.W. and Pandita, T.K. Single stranded DNA binding protein 1 facilitate TERT recruitment to telomeres and maintains telomere G-overhangs, Cancer Res, 75(5): 1-12, 2015.
  4. Kulak, O., Chen, H., Holohan, B., Wu, X., He, H., Borek, D., Otwinowski, Z., Yamaguchi, K., Garofalo, L. A., Ma, Z., Wright, W., Chen, C., Shay, J. W., Zhang, X. and Lum, L. (2015). Disruption of Wnt/beta-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells. Mol Cell Biol 35(14): 2425-2435.
  5. Meyer, C. J., Krauth, M., Wick, M. J., Shay, J. W., Gellert, G., De Brabander, J. K., Northcote, P. T. and Miller, J. H. (2015). Peloruside A Inhibits Growth of Human Lung and Breast Tumor Xenografts in an Athymic nu/nu Mouse Model. Mol Cancer Ther 14(8): 1816-1823.
  6. Holohan, B., De Meyer, T., Batten, K., Mangino, M., Hunt, S. C., Bekaert, S., De Buyzere, M. L., Rietzschel, E. R., Spector, T. D., Wright, W. E. and Shay, J. W. (2015). Decreasing initial telomere length in humans intergenerationally understates age-associated telomere shortening. Aging Cell 14(4): 669-677.
  7. Kulak, O., Chen, H., Holohan, B., Wu, X., He, H., Borek, D., Otwinowski, Z., Yamaguchi, K., Garofalo, L. A., Ma, Z., Wright, W., Chen, C., Shay, J. W., Zhang, X. and Lum, L. (2015). Disruption of Wnt/beta-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells. Mol Cell Biol 35(14): 2425-2435.
  8. Mender, I., Gryaznov, S. and Shay, J. W. (2015). A novel telomerase substrate precursor rapidly induces telomere dysfunction in telomerase positive cancer cells but not telomerase silent normal cells. Oncoscience 2(8): 693-695.
  9. Holohan, B., Hagiopian, M. M., Lai, T. P., Huang, E., Friedman, D. R., Wright, W. E. and Shay, J. W. (2015). Perifosine as a potential novel anti-telomerase therapy. Oncotarget 6(26): 21816-21826.
  10. Zhou, J., Mao, B., Zhou, Q., Ding, D., Wang, M., Guo, P., Gao, Y., Shay, J. W., Yuan, Z. and Cong, Y. S. (2014). Endoplasmic reticulum stress activates telomerase. Aging Cell 13(1): 197-200.
  11. Kim, S. B., Kaisani, A. and Shay, J. W. (2014). Risk assessment of space radiation-induced invasive cancer in mouse models of lung and colorectal cancer. Journal of radiation research 55(suppl 1): i46-i47.
  12. Shay, J. W. (2014). Are short telomeres hallmarks of cancer recurrence? Clin Cancer Res 20(4): 779-781.
  13. Delgado, O., Batten, K. G., Richardson, J. A., Xie, X. J., Gazdar, A. F., Kaisani, A. A., Girard, L., Behrens, C., Suraokar, M., Fasciani, G., Wright, W. E., Story, M. D., Wistuba, II, Minna, J. D. and Shay, J. W. (2014). Radiation-enhanced lung cancer progression in a transgenic mouse model of lung cancer is predictive of outcomes in human lung and breast cancer. Clin Cancer Res 20(6): 1610-1622.
  14. Wong, M. S., Shay, J. W. and Wright, W. E. (2014). Regulation of human telomerase splicing by RNA:RNA pairing. Nat Commun 5: 3306.
  15. Kim, S. B., Zhang, L., Barron, S. and Shay, J. W. (2014). Inhibition of microRNA-31-5p protects human colonic epithelial cells against ionizing radiation. Life Sci Space Res (Amst) 1: 67-73.
  16. Kaisani, A., Delgado, O., Fasciani, G., Kim, S. B., Wright, W. E., Minna, J. D. and Shay, J. W. (2014). Branching morphogenesis of immortalized human bronchial epithelial cells in three-dimensional culture. Differentiation 87(3-4): 119-126.
  17. Singel, S. M., Cornelius, C., Zaganjor, E., Batten, K., Sarode, V. R., Buckley, D. L., Peng, Y., John, G. B., Li, H. C., Sadeghi, N., Wright, W. E., Lum, L., Corson, T. W. and Shay, J. W. (2014). KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancer. Neoplasia 16(3): 247-256, 256 e242.
  18. Singel, S. M., Batten, K., Cornelius, C., Jia, G., Fasciani, G., Barron, S. L., Wright, W. E. and Shay, J. W. (2014). Receptor-interacting protein kinase 2 promotes triple-negative breast cancer cell migration and invasion via activation of nuclear factor-kappaB and c-Jun N-terminal kinase pathways. Breast Cancer Res 16(2): R28.
  19. Holohan, B., Wright, W. E. and Shay, J. W. (2014). Cell biology of disease: Telomeropathies: an emerging spectrum disorder. J Cell Biol 205(3): 289-299.
  20. Wong, M. S., Wright, W. E. and Shay, J. W. (2014). Alternative splicing regulation of telomerase: a new paradigm? Trends Genet 30(10): 430-438.
  21. Ludlow, A. T., Robin, J. D., Sayed, M., Litterst, C. M., Shelton, D. N., Shay, J. W. and Wright, W. E. (2014). Quantitative telomerase enzyme activity determination using droplet digital PCR with single cell resolution. Nucleic Acids Res 42(13): e104.
  22. Robin, J. D., Ludlow, A. T., Batten, K., Magdinier, F., Stadler, G., Wagner, K. R., Shay, J. W. and Wright, W. E. (2014). Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances. Genes Dev 28(22): 2464-2476.
  23. El-Ashmawy, M., Delgado, O., Cardentey, A., Wright, W. E. and Shay, J. W. (2014). CDDO-Me protects normal lung and breast epithelial cells but not cancer cells from radiation. PLoS One 9(12): e115600.
  24. Zhang, L., Komurov, K., Wright, W. E. and Shay, J. W. (2013). Identification of novel driver tumor suppressors through functional interrogation of putative passenger mutations in colorectal cancer. Int J Cancer 132(3): 732-737.
  25. Christodoulidou, A., Raftopoulou, C., Chiourea, M., Papaioannou, G. K., Hoshiyama, H., Wright, W. E., Shay, J. W. and Gagos, S. (2013). The roles of telomerase in the generation of polyploidy during neoplastic cell growth. Neoplasia 15(2): 156-168.
  26. Singh, M., Hunt, C. R., Pandita, R. K., Kumar, R., Yang, C. R., Horikoshi, N., Bachoo, R., Serag, S., Story, M. D., Shay, J. W., Powell, S. N., Gupta, A., Jeffery, J., Pandita, S., Chen, B. P., Deckbar, D., Lobrich, M., Yang, Q., Khanna, K. K., Worman, H. J. and Pandita, T. K. (2013). Lamin A/C depletion enhances DNA damage-induced stalled replication fork arrest. Mol Cell Biol 33(6): 1210-1222.
  27. Mender, I., Senturk, S., Ozgunes, N., Akcali, K. C., Kletsas, D., Gryaznov, S., Can, A., Shay, J. W. and Dikmen, Z. G. (2013). Imetelstat (a telomerase antagonist) exerts offtarget effects on the cytoskeleton. Int J Oncol 42(5): 1709-1715.
  28. Hunt, C. R., Ramnarain, D., Horikoshi, N., Iyengar, P., Pandita, R. K., Shay, J. W. and Pandita, T. K. (2013). Histone modifications and DNA double-strand break repair after exposure to ionizing radiations. Radiat Res 179(4): 383-392.
  29. Wong, M. S., Chen, L., Foster, C., Kainthla, R., Shay, J. W. and Wright, W. E. (2013). Regulation of telomerase alternative splicing: a target for chemotherapy. Cell Rep 3(4): 1028-1035.
  30. Stadler, G., Rahimov, F., King, O. D., Chen, J. C., Robin, J. D., Wagner, K. R., Shay, J. W., Emerson, C. P., Jr. and Wright, W. E. (2013). Telomere position effect regulates DUX4 in human facioscapulohumeral muscular dystrophy. Nat Struct Mol Biol 20(6): 671-678.
  31. Sato, M., Larsen, J. E., Lee, W., Sun, H., Shames, D. S., Dalvi, M. P., Ramirez, R. D., Tang, H., DiMaio, J. M., Gao, B., Xie, Y., Wistuba, II, Gazdar, A. F., Shay, J. W. and Minna, J. D. (2013). Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations. Mol Cancer Res 11(6): 638-650.
  32. Singel, S. M., Cornelius, C., Batten, K., Fasciani, G., Wright, W. E., Lum, L. and Shay, J. W. (2013). A targeted RNAi screen of the breast cancer genome identifies KIF14 and TLN1 as genes that modulate docetaxel chemosensitivity in triple-negative breast cancer. Clin Cancer Res 19(8): 2061-2070.
  33. Ghayee, H. K., Bhagwandin, V. J., Stastny, V., Click, A., Ding, L. H., Mizrachi, D., Zou, Y. S., Chari, R., Lam, W. L., Bachoo, R. M., Smith, A. L., Story, M. D., Sidhu, S., Robinson, B. G., Nwariaku, F. E., Gazdar, A. F., Auchus, R. J. and Shay, J. W. (2013). Progenitor cell line (hPheo1) derived from a human pheochromocytoma tumor. PLoS One 8(6): e65624.
  34. Kim, S. B., Ly, P., Kaisani, A., Zhang, L., Wright, W. E. and Shay, J. W. (2013). Mitigation of radiation-induced damage by targeting EGFR in noncancerous human epithelial cells. Radiat Res 180(3): 259-267.
  35. Shay, J. W. (2013). Determining if telomeres matter in colon cancer initiation or progression. J Natl Cancer Inst 105(16): 1166-1168.
  36. Ghayee, H. K., Giubellino, A., Click, A., Kapur, P., Christie, A., Xie, X. J., Martucci, V., Shay, J. W., Souza, R. F. and Pacak, K. (2013). Phospho-mTOR is not upregulated in metastatic SDHB paragangliomas. Eur J Clin Invest 43(9): 970-977.
  37. Stadler, G., King, O. D., Robin, J. D., Shay, J. W. and Wright, W. E. (2013). Facioscapulohumeral muscular dystrophy: Are telomeres the end of the story? Rare Dis 1: e26142.
  38. Shay, J. W. (2013). Are short telomeres predictive of advanced cancer? Cancer Discov 3(10): 1096-1098.
  39. Ly, P., Kim, S. B., Kaisani, A. A., Marian, G., Wright, W. E. and Shay, J. W. (2013). Aneuploid human colonic epithelial cells are sensitive to AICAR-induced growth inhibition through EGFR degradation. Oncogene 32(26): 3139-3146.
  40. Chow, T. T., Zhao, Y., Mak, S. S., Shay, J. W. and Wright, W. E. (2012). Early and late steps in telomere overhang processing in normal human cells: the position of the final RNA primer drives telomere shortening. Genes Dev 26(11): 1167-1178.
  41. Shay, J. W., Reddel, R. R. and Wright, W. E. (2012). Cancer. Cancer and telomeres--an ALTernative to telomerase. Science 336(6087): 1388-1390.
  42. Ly, P., Eskiocak, U., Parker, C. R., Harris, K. J., Wright, W. E. and Shay, J. W. (2012). RNAi screening of the human colorectal cancer genome identifies multifunctional tumor suppressors regulating epithelial cell invasion. Cell Res 22(11): 1605-1608.
  43. Kim, S. B., Pandita, R. K., Eskiocak, U., Ly, P., Kaisani, A., Kumar, R., Cornelius, C., Wright, W. E., Pandita, T. K. and Shay, J. W. (2012). Targeting of Nrf2 induces DNA damage signaling and protects colonic epithelial cells from ionizing radiation. Proc Natl Acad Sci U S A 109(43): E2949-2955.