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Moriya Tsuji
  • HIV and Malaria Vaccine Program, Aaron Diamond AIDS Research Center, USA
研究方向
  • Immunology
个人信息

Education

M.D. The Jikei University School of Medicine, Tokyo, Japan, 1983

Ph.D. in Immunology, University of Tokyo, Faculty of Medicine, 1987

Current position

Aaron Diamond Professor at The Rockefeller University, Staff Investigator, HIV and Malaria Vaccine Program, Aaron Diamond AIDS Research Center, New York, NY USA.

Publications (since 2005)

  1. Coelho-dos-Reis, J. G., Li, X., Silveira, ELV., Mandraju, R., Velmurugan, S., Chakravarty, S., Suemizu, H., Ito, M., Sim, BKL., Hoffman, S. L. and Tsuji, M. (2013). Plasmodium falciparum infection in “humanized liver” mice. Malaria World J. In press.
  2. Kelly, H., Mandraju, R., Coelho-dos-Reis, J. G. and Tsuji, M. (2013). Effects of HIV-1-induced CD1c and CD1d modulation and endogenous lipid presentation on CD1c-restricted T-cell activation. BMC Immunol 14: 4.
  3. Huang, J., Li, X., Kohno, K., Hatano, M., Tokuhisa, T., Murray, P. J., Brocker, T. and Tsuji, M. (2013). Generation of tissue-specific H-2Kd transgenic mice for the study of K(d)-restricted malaria epitope-specific CD8+ T-cell responses in vivo. J Immunol Methods 387(1-2): 254-261.
  4. Avci, F. Y., Li, X., Tsuji, M. and Kasper, D. L. (2012). Isolation of carbohydrate-specific CD4(+) T cell clones from mice after stimulation by two model glycoconjugate vaccines. Nat Protoc 7(12): 2180-2192.
  5. Li, X., Polacino, P., Garcia-Navarro, R., Hu, S. L. and Tsuji, M. (2012). Peripheral blood invariant natural killer T cells of pig-tailed macaques. PLoS ONE 7(10): e48166..
  6. Webb, T. J., Li, X., Giuntoli, R. L., 2nd, Lopez, P. H., Heuser, C., Schnaar, R. L., Tsuji, M., Kurts, C., Oelke, M. and Schneck, J. P. (2012). Molecular identification of GD3 as a suppressor of the innate immune response in ovarian cancer. Cancer Res 72(15): 3744-3752.
  7. Rai, U., Huang, J., Mishra, S., Li, X., Shiratsuchi, T. and Tsuji, M. (2012). A New Method to Determine Antigen-Specific CD8+ T Cell Activity in Vivo by Hydrodynamic Injection. Biomolecules 2(1): 23-33.
  8. Avci, F. Y., Li, X., Tsuji, M. and Kasper, D. L. (2011). A mechanism for glycoconjugate vaccine activation of the adaptive immune system and its implications for vaccine design. Nat Med 17(12): 1602-1609.
  9. Kinjo, Y., Illarionov, P., Vela, J. L., Pei, B., Girardi, E., Li, X., Li, Y., Imamura, M., Kaneko, Y., Okawara, A., Miyazaki, Y., Gomez-Velasco, A., Rogers, P., Dahesh, S., Uchiyama, S., Khurana, A., Kawahara, K., Yesilkaya, H., Andrew, P. W., Wong, C. H., Kawakami, K., Nizet, V., Besra, G. S., Tsuji, M., Zajonc, D. M. and Kronenberg, M. (2011). Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria. Nat Immunol 12(10): 966-974.
  10. Mishra, S., Rai, U., Shiratsuchi, T., Li, X., Vanloubbeeck, Y., Cohen, J., Nussenzweig, R. S., Winzeler, E. A., Tsuji, M. and Nussenzweig, V. (2011). Identification of non-CSP antigens bearing CD8 epitopes in mice immunized with irradiated sporozoites. Vaccine 29(43): 7335-7342.
  11. Padte, N. N., Li, X., Tsuji, M. and Vasan, S. (2011). Clinical development of a novel CD1d-binding NKT cell ligand as a vaccine adjuvant. Clin Immunol 140(2): 142-151.
  12. Shiratsuchi, T., Rai, U., Krause, A., Worgall, S. and Tsuji, M. (2010). Replacing adenoviral vector HVR1 with a malaria B cell epitope improves immunogenicity and circumvents preexisting immunity to adenovirus in mice. J Clin Invest 120(10): 3688-3701.
  13. Li, X., Fujio, M., Imamura, M., Wu, D., Vasan, S., Wong, C. H., Ho, D. D. and Tsuji, M. (2010). Design of a potent CD1d-binding NKT cell ligand as a vaccine adjuvant. Proc Natl Acad Sci U S A 107(29): 13010-13015.
  14. Tsuji, M. (2010). A retrospective evaluation of the role of T cells in the development of malaria vaccine. Exp Parasitol 126(3): 421-425.
  15. Lombardi, V., Stock, P., Singh, A. K., Kerzerho, J., Yang, W., Sullivan, B. A., Li, X., Shiratsuchi, T., Hnatiuk, N. E., Howell, A. R., Yu, K. O., Porcelli, S. A., Tsuji, M., Kronenberg, M., Wilson, S. B. and Akbari, O. (2010). A CD1d-dependent antagonist inhibits the activation of invariant NKT cells and prevents development of allergen-induced airway hyperreactivity. J Immunol 184(4): 2107-2115.
  16. Schmieg, J., Yang, G., Franck, R. W. and Tsuji, M. (2010). A multifactorial mechanism in the superior antimalarial activity of alpha-C-GalCer. J Biomed Biotechnol 2010: 283612.
  17. Vasan, S. and Tsuji, M. (2010). A double-edged sword: the role of NKT cells in malaria and HIV infection and immunity. Semin Immunol 22(2): 87-96.
  18. Sullivan, B. A., Nagarajan, N. A., Wingender, G., Wang, J., Scott, I., Tsuji, M., Franck, R. W., Porcelli, S. A., Zajonc, D. M. and Kronenberg, M. (2010). Mechanisms for glycolipid antigen-driven cytokine polarization by Valpha14i NKT cells. J Immunol 184(1): 141-153.
  19. Horowitz, A., Li, X., Poles, M. A. and Tsuji, M. (2009). Use of immobilized HLA-A2:Ig dimeric proteins to determine the level of epitope-specific, HLA-restricted CD8(+) T-cell response. Scand J Immunol 70(5): 415-422.
  20. Li, X., Shiratsuchi, T., Chen, G., Dellabona, P., Casorati, G., Franck, R. W. and Tsuji, M. (2009). Invariant TCR rather than CD1d shapes the preferential activities of C-glycoside analogues against human versus murine invariant NKT cells. J Immunol 183(7): 4415-4421.
  21. Kopecky-Bromberg, S. A., Fraser, K. A., Pica, N., Carnero, E., Moran, T. M., Franck, R. W., Tsuji, M. and Palese, P. (2009). Alpha-C-galactosylceramide as an adjuvant for a live attenuated influenza virus vaccine. Vaccine 27(28): 3766-3774.
  22. Li, X., Chen, G., Garcia-Navarro, R., Franck, R. W. and Tsuji, M. (2009). Identification of C-glycoside analogues that display a potent biological activity against murine and human invariant natural killer T cells. Immunology 127(2): 216-225.
  23. Shiratsuchi, T., Schneck, J., Kawamura, A. and Tsuji, M. (2009). Human CD1 dimeric proteins as indispensable tools for research on CD1-binding lipids and CD1-restricted T cells. J Immunol Methods 345(1-2): 49-59.
  24. Grajewski, R. S., Hansen, A. M., Agarwal, R. K., Kronenberg, M., Sidobre, S., Su, S. B., Silver, P. B., Tsuji, M., Franck, R. W., Lawton, A. P., Chan, C. C. and Caspi, R. R. (2008). Activation of invariant NKT cells ameliorates experimental ocular autoimmunity by a mechanism involving innate IFN-gamma production and dampening of the adaptive Th1 and Th17 responses. J Immunol 181(7): 4791-4797.
  25. Liang, P. H., Imamura, M., Li, X., Wu, D., Fujio, M., Guy, R. T., Wu, B. C., Tsuji, M. and Wong, C. H. (2008). Quantitative microarray analysis of intact glycolipid-CD1d interaction and correlation with cell-based cytokine production. J Am Chem Soc 130(37): 12348-12354.
  26. Desruisseaux, M. S., Gulinello, M., Smith, D. N., Lee, S. C., Tsuji, M., Weiss, L. M., Spray, D. C. and Tanowitz, H. B. (2008). Cognitive dysfunction in mice infected with Plasmodium berghei strain ANKA. J Infect Dis 197(11): 1621-1627.
  27. Huang, Y., Chen, A., Li, X., Chen, Z., Zhang, W., Song, Y., Gurner, D., Gardiner, D., Basu, S., Ho, D. D. and Tsuji, M. (2008). Enhancement of HIV DNA vaccine immunogenicity by the NKT cell ligand, alpha-galactosylceramide. Vaccine 26(15): 1807-1816.
  28. Singhal, P., Mischo, A., Li, Q. S., Eppolito, C., Tsuji, M., Franke, M., Lele, S., Odunsi, K. and Shrikant, P. (2007). The natural killer T-cell ligand alpha-C-galactosylceramide promotes ovarian cancer survival by dual regulation of the adaptive host immunity. Gyn Oncology104: S21.
  29. Vasan, S., Poles, M. A., Horowitz, A., Siladji, E. E., Markowitz, M. and Tsuji, M. (2007). Function of NKT cells, potential anti-HIV effector cells, are improved by beginning HAART during acute HIV-1 infection. Int Immunol 19(8): 943-951.
  30. Coppieters, K., Van Beneden, K., Jacques, P., Dewint, P., Vervloet, A., Vander Cruyssen, B., Van Calenbergh, S., Chen, G., Franck, R. W., Verbruggen, G., Deforce, D., Matthys, P., Tsuji, M., Rottiers, P. and Elewaut, D. (2007). A single early activation of invariant NK T cells confers long-term protection against collagen-induced arthritis in a ligand-specific manner. J Immunol 179(4): 2300-2309.
  31. Teng, M. W., Westwood, J. A., Darcy, P. K., Sharkey, J., Tsuji, M., Franck, R. W., Porcelli, S. A., Besra, G. S., Takeda, K., Yagita, H., Kershaw, M. H. and Smyth, M. J. (2007). Combined natural killer T-cell based immunotherapy eradicates established tumors in mice. Cancer Res 67(15): 7495-7504.
  32. Ophorst, O., Radosevic, K., Verhaagh, S., de Gruijl T., Pau, M. G., Berkhout, B., Tsuji, M., Goudsmit, J. and Havenga, M. (2006). Pre-clinical studies towards rAd35-based malaria vaccines. Am J Trop Med Hyg. 75: 304.
  33. Franck, R. W. and Tsuji, M. (2006). Alpha-c-galactosylceramides: synthesis and immunology. Acc Chem Res 39(10): 692-701.
  34. Van Beneden K., Coppieters, K., Vervloe, A., Vandercruyssen, B., Jacques, P., Dewint, P., De Klerck B., Heremans, H., Tsuji, M., Verbruggen, G., Deforce, D., Matthys, P. and Elewaut, D. (2006). Long-term IFN-gamma dependent efficacy of activated valpha141 natural killer T cells in the prevention of collagen-induced arthritis. Annals Rheum Dis65: 141
  35. Kinjo, Y., Tupin, E., Wu, D., Fujio, M., Garcia-Navarro, R., Benhnia, M. R., Zajonc, D. M., Ben-Menachem, G., Ainge, G. D., Painter, G. F., Khurana, A., Hoebe, K., Behar, S. M., Beutler, B., Wilson, I. A., Tsuji, M., Sellati, T. J., Wong, C. H. and Kronenberg, M. (2006). Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria. Nat Immunol 7(9): 978-986.
  36. Fujii, S., Shimizu, K., Hemmi, H., Fukui, M., Bonito, A. J., Chen, G., Franck, R. W., Tsuji, M. and Steinman, R. M. (2006). Glycolipid alpha-C-galactosylceramide is a distinct inducer of dendritic cell function during innate and adaptive immune responses of mice. Proc Natl Acad Sci U S A 103(30): 11252-11257.
  37. Tsuji, M. (2006). Glycolipids and phospholipids as natural CD1d-binding NKT cell ligands. Cell Mol Life Sci 63(16): 1889-1898.
  38. Fujio, M., Wu, D., Garcia-Navarro, R., Ho, D. D., Tsuji, M. and Wong, C. H. (2006). Structure-based discovery of glycolipids for CD1d-mediated NKT cell activation: tuning the adjuvant versus immunosuppression activity. J Am Chem Soc 128(28): 9022-9023.
  39. Chen, G., Chien, M., Tsuji, M. and Franck, R. W. (2006). E and Z alpha-C-galactosylceramides by Julia-Lythgoe-Kocienski chemistry: a test of the receptor-binding model for glycolipid immunostimulants. Chembiochem 7(7): 1017-1022.
  40. Coppieters, K., Van Beneden K., Vervloet, A., Dewint, P., Jacques, P., Groeneboer, S., Tsuji, M., Verbruggen, G., Deforce, D., Matthys, P., Rottiers, P. and Elewaut, D. (2006). Long-term IFN-gamma dependent efficacy of activated V alpha 14I natural killer T-cells in the prevention of collagen-induced arthritis.Clin. Immunol. 119: S62
  41. Machado, F. S., Desruisseaux, M. S., Nagajyothi, Kennan, R. P., Hetherington, H. P., Wittner, M., Weiss, L. M., Lee, S. C., Scherer, P. E., Tsuji, M. and Tanowitz, H. B. (2006). Endothelin in a murine model of cerebral malaria. Exp Biol Med (Maywood) 231(6): 1176-1181.
  42. Ophorst, O. J., Radosevic, K., Havenga, M. J., Pau, M. G., Holterman, L., Berkhout, B., Goudsmit, J. and Tsuji, M. (2006). Immunogenicity and protection of a recombinant human adenovirus serotype 35-based malaria vaccine against Plasmodium yoelii in mice. Infect Immun 74(1): 313-320.
  43. Kennan, R. P., Machado, F. S., Lee, S. C., Desruisseaux, M. S., Wittner, M., Tsuji, M. and Tanowitz, H. B. (2005). Reduced cerebral blood flow and N-acetyl aspartate in a murine model of cerebral malaria. Parasitol Res 96(5): 302-307.
  44. Kinjo, Y., Wu, D., Kim, G., Xing, G. W., Poles, M. A., Ho, D. D., Tsuji, M., Kawahara, K., Wong, C. H. and Kronenberg, M. (2005). Recognition of bacterial glycosphingolipids by natural killer T cells. Nature 434(7032): 520-525.
  45. Xing, G. W., Wu, D., Poles, M. A., Horowitz, A., Tsuji, M., Ho, D. D. and Wong, C. H. (2005). Synthesis and human NKT cell stimulating properties of 3-O-sulfo-alpha/beta-galactosylceramides. Bioorg Med Chem 13(8): 2907-2916.
  46. Wu, D., Xing, G. W., Poles, M. A., Horowitz, A., Kinjo, Y., Sullivan, B., Bodmer-Narkevitch, V., Plettenburg, O., Kronenberg, M., Tsuji, M., Ho, D. D., Wong, C. H. (2005). Novel bacterial glycolipids and analogues as antigens for CD1d-restricted NKT cells. Proc Natl Acad Sci U S A 102: 1352 -1356.
  47. Schmieg, J., Yang, G., Franck, R. W., Van Rooijen, N. and Tsuji, M. (2005). Glycolipid presentation to natural killer T cells differs in an organ-dependent fashion. Proc Natl Acad Sci U S A 102(4): 1127-1132.
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