联合作者(
Vincent Grossi Univ Lyon, Univ. Lyon 1, ENSL, CNRS, UMR 5276 LGL-TPE, F-69622 Villeurbanne, France
1 protocol

Philippe Schaeffer Univ. Strasbourg, CNRS, UMR 7177, F-67000 Strasbourg, France
1 protocol

Maxime Tourte
1 protocol

Philippe M. Oger
  • Faculty, Univ Lyon, INSA Lyon, CNRS, UMR 5240, F-69621,, Villeurbanne
研究方向
  • My research aims at deciphering — from the atomic to the genetic level — the behavior and adaptation of Archaea in response to environmental stresses. The aim is to explore the limits of life in the deep-biosphere, with an emphasis on the adaptation to hydrostatic pressure, temperature and salinity variations in deep-sea hydrothermal vents. Over the years I have helped develop the two widely accepted hypethermophilic archaea, e.g. Thermococcus barophilus and Pyrococcus yayanosii, as genetic models for the study of high-hydrostatic pressure adaptation. My approaches are multi- and trans-disciplinary since I aim at understanding the physics at work in the physiologic adaptation of cells. To this avail I use techniques ranging from spectral physics (Xray and Neutron diffraction and diffusion) to meta-omics (meta-genome sequencing, RNASeq and Proteomics) in order to track the genetic imprint of these adaptations from the cell level to the molecule.
    This combination of approaches has led to several major scientific discoveries over the last years. First, I have described the first atomistic model of high hydrostatic pressure adaptation (Martinez Sci Rep 2016; Cario Sci Rep 2016; Salvador-Castell Soft Matter 2020) and second I have described and validated a novel membrane ultrstructure as a new adaptation strategy to high hydrostatic pressure and temperature in hyperthermophilic Archaea (Cario Front Microbiol 2015; Salvador-Castell Langmuir 2020; Tourte Front Microbiol 2020).
  • 已发表 protocol 1

教育背景

PhD, University of Paris XI, 1995

实验室信息

Microbiology, Adaptation and Pathogeny
https://map.insa-lyon.fr/en/node/130

发表论文

已发表 protocol 1篇
Acid Hydrolysis for the Extraction of Archaeal Core Lipids and HPLC-MS Analysis
酸水解法提取古生菌核心脂质及HPLC-MS分析

作者:Maxime Tourte, Philippe Schaeffer, Vincent Grossi and Philippe M. Oger日期:08/20/2021,浏览量:460,Q&A: 0

Lipid membranes are essential cellular elements as they provide cellular integrity and selective permeability under a broad range of environmental settings upon cell growth. In particular, Archaea are commonly recognized for their tolerance to

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