Education

MD, PhD, Shanghai Medical University/SUNY Buffalo, China/USA, 1999

Current position

Associate Professor, Pathology, Case Western Reserve University, USA

Publications

1. Original peer-reviewed articles published: 
   
   
   1. Kong, G., Chang, Y., Zhang, J., Ranheim, E. A., Zhang, X., Zhou, Y., Liu, Y., Sullivan, R., Zhou, L.,  Pear, W. S. and Zhang. J. (2018). Downregulating Notch counteracts KrasG12D-induced ERK activation and oxidative phosphorylation in myeloproliferative neoplasm. Leukemia (in revision).
      
      
   2. Murata, A., Hikosaka, M., Yoshino, M., Zhou, L. and Hayashi, S. (2018). C-kit-independent Mast Cell Adhesion by Notch. Int J. Immunology (in revision).
      
      
   3. Yu, S., Parameswaran, N., Li, M., Wang, Y., Jackson, M. W., Liu, H., Xin, W. and Zhou, L. (2017). CRABP-II enhances pancreatic cancer cell migration and invasion by stabilizing interleukin 8 expression. Oncotarget 8(32): 52432-52444.
      
      
   4. Wang, Y., Huang, D., Chen, K. Y., Cui, M., Wang, W., Huang, X., Awadellah, A., Li, Q., Friedman, A., Xin, W. W., Di Martino, L., Cominelli, F., Miron, A., Chan, R., Fox, J. G., Xu, Y., Shen, X., Kalady, M. F., Markowitz, S., Maillard, I., Lowe, J. B., Xin, W. and Zhou, L. (2017). Fucosylation Deficiency in Mice Leads to Colitis and Adenocarcinoma. Gastroenterology 152(1): 193-205 e110.
      
      
   5. Wang, W., Yu, S., Myers, J., Wang, Y., Xin, W. W., Albakri, M., Xin, A. W., Li, M., Huang, A. Y., Xin, W., Siebel, C. W., Lazarus, H. M. and Zhou, L. (2017). Notch2 blockade enhances hematopoietic stem cell mobilization and homing. Haematologica 102(10): 1785-1795.
      
      
   6. Cui, M., Awadallah, A., Liu, W., Zhou, L. and Xin, W. (2016). Loss of Hes1 Differentiates Sessile Serrated Adenoma/Polyp From Hyperplastic Polyp. Am J Surg Pathol 40(1): 113-119.
      
      
   7. Wang, W., Zimmerman, G., Huang, X., Yu, S., Myers, J., Wang, Y., Moreton, S., Nthale, J., Awadallah, A., Beck, R., Xin, W., Wald, D., Huang, A. Y. and Zhou, L. (2016). Aberrant Notch Signaling in the Bone Marrow Microenvironment of Acute Lymphoid Leukemia Suppresses Osteoblast-Mediated Support of Hematopoietic Niche Function. Cancer Res 76(6): 1641-1652.
      
      
   8. Wang, Y., Yu, S., Huang, D., Cui, M., Hu, H., Zhang, L., Wang, W., Parameswaran, N., Jackson, M., Osborne, B., Bedogni, B., Li, C., Sy, M. S., Xin, W. and Zhou, L. (2016). Cellular Prion Protein Mediates Pancreatic Cancer Cell Survival and Invasion through Association with and Enhanced Signaling of Notch1. Am J Pathol 186(11): 2945-2956.
      
      
   9. Gong, S., Schmotzer, C. L. and Zhou, L. (2016). Evaluation of Quantitative Real-Time PCR as a Hepatitis C Virus Supplementary Test After RIBA Discontinuation. J Clin Lab Anal 30(5): 418-423.
      
      
   10. Yu, V. W., Saez, B., Cook, C., Lotinun, S., Pardo-Saganta, A., Wang, Y. H., Lymperi, S., Ferraro, F., Raaijmakers, M. H., Wu, J. Y., Zhou, L., Rajagopal, J., Kronenberg, H. M., Baron, R. and Scadden, D. T. (2015). Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow. J Exp Med 212(5): 759-774.
       
       
   11. Wang, W., Yu, S., Zimmerman, G., Wang, Y., Myers, J., Yu, V. W., Huang, D., Huang, X., Shim, J., Huang, Y., Xin, W., Qiao, P., Yan, M., Xin, W., Scadden, D. T., Stanley, P., Lowe, J. B., Huang, A. Y., Siebel, C. W. and Zhou, L. (2015). Notch Receptor-Ligand Engagement Maintains Hematopoietic Stem Cell Quiescence and Niche Retention. Stem Cells 33(7): 2280-2293.
       
       
   12. Conde, P., Rodriguez, M., van der Touw, W., Jimenez, A., Burns, M., Miller, J., Brahmachary, M., Chen, H. M., Boros, P., Rausell-Palamos, F., Yun, T. J., Riquelme, P., Rastrojo, A., Aguado, B., Stein-Streilein, J., Tanaka, M., Zhou, L., Zhang, J., Lowary, T. L., Ginhoux, F., Park, C. G., Cheong, C., Brody, J., Turley, S. J., Lira, S. A., Bronte, V., Gordon, S., Heeger, P. S., Merad, M., Hutchinson, J., Chen, S. H. and Ochando, J. (2015). DC-SIGN(+) Macrophages Control the Induction of Transplantation Tolerance. Immunity 42(6): 1143-1158.
       
       
   13. Richardson, E. T., Shukla, S., Nagy, N., Boom, W. H., Beck, R. C., Zhou, L., Landreth, G. E. and Harding, C. V. (2015). ERK Signaling Is Essential for Macrophage Development. PLoS One 10(10): e0140064.
       
       
   14. Xiao, W., Hong, H., Awadallah, A., Zhou, L. and Xin, W. (2014). Utilization of CDX2 expression in diagnosing pancreatic ductal adenocarcinoma and predicting prognosis. PLoS One 9(1): e86853.
       
       
   15. Xiao, W., Hong, H., Awadallah, A., Yu, S., Zhou, L. and Xin, W. (2014). CRABP-II is a highly sensitive and specific diagnostic molecular marker for pancreatic ductal adenocarcinoma in distinguishing from benign pancreatic conditions. Hum Pathol 45(6): 1177-1183.
       
       
   16. Maitta, R., Zhou, L. (2014). Immature platelet fraction: coming of age of an underutilized test in the setting of thrombotic thrombocytopenic purpura. J Blood Disord Transfus  5: e114.
       
       
   17. Murata, A., Yoshino, M., Hikosaka, M., Okuyama, K., Zhou, L., Sakano, S., Yagita, H. and Hayashi, S. (2014). An evolutionary-conserved function of mammalian notch family members as cell adhesion molecules. PLoS One 9(9): e108535.
       
       
   18. Hu, H., Zhou, L., Awadallah, A. and Xin, W. (2013). Significance of Notch1-signaling pathway in human pancreatic development and carcinogenesis. Appl Immunohistochem Mol Morphol 21(3): 242-247.
       
       
   19. Wojewoda, C. M., Spahlinger, T., Harmon, M. L., Schnellinger, B., Li, Q., Dejelo, C., Schmotzer, C. and Zhou, L. (2013). Comparison of Roche Cobas AmpliPrep/Cobas TaqMan HIV-1 test version 2.0 (CAP/CTM v2.0) with other real-time PCR assays in HIV-1 monitoring and follow-up of low-level viral loads. J Virol Methods 187(1): 1-5.
       
       
   20. Singh, A., Haldar, S., Horback, K., Tom, C., Zhou, L., Meyerson, H. and Singh, N. (2013). Prion protein regulates iron transport by functioning as a ferrireductase. J Alzheimers Dis 35(3): 541-552.
       
       
   21. Zhou, L. (2012). Myeloproliferation and hematopoietic stem cell dysfunction due to defective Notch receptor modification by O-fucose glycans. Semin Immunopathol 34(3): 455-469.
       
       
   22. Schmotzer, C. L. and Zhou, L. (2012). Risk of false positive hepatitis C virus RNA due to sample to sample carryover on an automated hematology analyzer. Clin Chem Lab Med 50(12): 2235-2236.
       
       
   23. Yao, D., Huang, Y., Huang, X., Wang, W., Yan, Q., Wei, L., Xin, W., Gerson, S., Stanley, P., Lowe, J. B. and Zhou, L. (2011). Protein O-fucosyltransferase 1 (Pofut1) regulates lymphoid and myeloid homeostasis through modulation of Notch receptor ligand interactions. Blood 117(21): 5652-5662.
       
       
   24. Esper, F. P., Spahlinger, T. and Zhou, L. (2011). Rate and influence of respiratory virus co-infection on pandemic (H1N1) influenza disease. J Infect 63(4): 260-266.
       
       
   25. Sy, M. S., Altekruse, S. F., Li, C., Lynch, C. F., Goodman, M. T., Hernandez, B. Y., Zhou, L., Saber, M. S., Hewitt, S. M. and Xin, W. (2011). Association of prion protein expression with pancreatic adenocarcinoma survival in the SEER residual tissue repository. Cancer Biomark 10(6): 251-258.
       
       
   26. Yan, Q., Yao, D., Wei, L. L., Huang, Y., Myers, J., Zhang, L., Xin, W., Shim, J., Man, Y., Petryniak, B., Gerson, S., Lowe, J. B. and Zhou, L. (2010). O-fucose modulates Notch-controlled blood lineage commitment. Am J Pathol 176(6): 2921-2934.
       
       
   27. Myers, J., Huang, Y., Wei, L., Yan, Q., Huang, A. and Zhou, L. (2010). Fucose-deficient hematopoietic stem cells have decreased self-renewal and aberrant marrow niche occupancy. Transfusion 50(12): 2660-2669.
       
       
   28. Zhou, L., Li, L. W., Yan, Q., Petryniak, B., Man, Y., Su, C., Shim, J., Chervin, S. and Lowe, J. B. (2008). Notch-dependent control of myelopoiesis is regulated by fucosylation. Blood 112(2): 308-319.
       
       
   29. Hoffmann, S., Zhou, L., Gu, Y., Davenport, R. and Cooling, L. (2005). Delayed platelet engraftment in group O patients after autologous progenitor cell transplantation. Transfusion 45(6): 885-895.
       
       
   30. Zhou, L., Giacherio, D., Cooling, L. and Davenport, R. D. (2005). Use of B-natriuretic peptide as a diagnostic marker in the differential diagnosis of transfusion-associated circulatory overload. Transfusion 45(7): 1056-1063.
       
       
   31. Zhou, L. and Schmaier, A. H. (2005). Platelet aggregation testing in platelet-rich plasma: description of procedures with the aim to develop standards in the field. Am J Clin Pathol 123(2): 172-183.
       
       
   32. Zhou, L., Thorson, J. A., Nugent, C., Davenport, R. D., Butch, S. H. and Judd, W. J. (2005). Noninvasive prenatal RHD genotyping by real-time polymerase chain reaction using plasma from D-negative pregnant women. Am J Obstet Gynecol 193(6): 1966-1971.
       
       
   33. Smith, P. L., Myers, J. T., Rogers, C. E., Zhou, L., Petryniak, B., Becker, D. J., Homeister, J. W. and Lowe, J. B. (2002). Conditional control of selectin ligand expression and global fucosylation events in mice with a targeted mutation at the FX locus. J Cell Biol 158(4): 801-815.
       
       
   34. Skerrett, I. M., Merritt, M., Zhou, L., Zhu, H., Cao, F., Smith, J. F. and Nicholson, B. J. (2001). Applying the Xenopus oocyte expression system to the analysis of gap junction proteins. Methods Mol Biol 154: 225-249.
       
       
   35. Zhou, L., Kasperek, E. M. and Nicholson, B. J. (1999). Dissection of the molecular basis of pp60(v-src) induced gating of connexin 43 gap junction channels. J Cell Biol 144(5): 1033-1045.
       
       
   36. Foote, C. I., Zhou, L., Zhu, X. and Nicholson, B. J. (1998). The pattern of disulfide linkages in the extracellular loop regions of connexin 32 suggests a model for the docking interface of gap junctions. J Cell Biol 140(5): 1187-1197.
       
       
   37. Nicholson, B. J., Zhou, L., Cao, F., Zhu, H. and Chen, Y. (1998). Diverse molecular mechanisms of gap junction channel gating. In: Werner, R. (Ed.). Gap Junctions. IOS press, 3-7.
       
       
   38. Zhou, L. and Zhang, Z. (1997). Isolation and purification of gap junction proteins from various tissues. In: Zhang, J. (Ed.), Methods in Advanced Pharmacology. Beijing Medical University and Peking Union Medical University. 
       
       
   39. Zhou, L., Yang, X. P. and Chen, H. L. (1996). Blocking effect of retinoid acid on n-nitrosodiethylamin induced rat liver carcinoma. Chinese Biochemical Journal. 12(1): 104-108.