联合作者(
Andrés Ozaita 1 protocol

Giovanni Marsicano INSERM U1215 NEUROCENTRE MAGENDIE, UNIVERSITE DE BORDEAUX, FRANCE
5 protocols

Rafael Maldonado 2 protocols

联合评审(
Alexandra Gros CNES - University of Bordeaux (IMN)
7 protocols

Andrew L. Eagle Michigan State University
5 protocols

Edgar Soria-Gomez Faculty of Medicine and Nursery, University of the Basque Country
25 protocols

Emma Puighermanal Universitat Autònoma de Barcelona
4 protocols

编委
Arnau Busquets-Garcia
  • Junior researcher, IMIM, Parc de Recerca Biomedica, 2019-
研究方向
  • 神经科学
  • 已发表 protocol 3

教育背景

PhD, University Pompeu Fabra, 2009

发表论文

1. Busquets-Garcia, A., Soria-Gomez, E., Redon, B., Mackenbach, Y., Vallee, M., Chaouloff, F., Varilh, M., Ferreira, G., Piazza, P. V. and Marsicano, G. (2017). Pregnenolone blocks cannabinoid-induced acute psychotic-like states in mice. Mol Psychiatry.
2. Saravia, R., Flores, A., Plaza-Zabala, A., Busquets-Garcia, A., Pastor, A., de la Torre, R., Di Marzo, V., Marsicano, G., Ozaita, A., Maldonado, R. and Berrendero, F. (2017). CB1 Cannabinoid Receptors Mediate Cognitive Deficits and Structural Plasticity Changes During Nicotine Withdrawal. Biol Psychiatry 81(7): 625-634.
3. Hebert-Chatelain, E., Desprez, T., Serrat, R., Bellocchio, L., Soria-Gomez, E., Busquets-Garcia, A., Pagano Zottola, A. C., Delamarre, A., Cannich, A., Vincent, P., Varilh, M., Robin, L. M., Terral, G., Garcia-Fernandez, M. D., Colavita, M., Mazier, W., Drago, F., Puente, N., Reguero, L., Elezgarai, I., Dupuy, J. W., Cota, D., Lopez-Rodriguez, M. L., Barreda-Gomez, G., Massa, F., Grandes, P., Benard, G. and Marsicano, G. (2016). A cannabinoid link between mitochondria and memory. Nature 539(7630): 555-559.
4. Gomis-Gonzalez, M., Busquets-Garcia, A., Matute, C., Maldonado, R., Mato, S. and Ozaita, A. (2016). Possible Therapeutic Doses of Cannabinoid Type 1 Receptor Antagonist Reverses Key Alterations in Fragile X Syndrome Mouse Model. Genes (Basel) 7(9).
5. Ramos-Fernandez, E., Tajes, M., Ill-Raga, G., Vargas, L., Busquets-Garcia, A., Bosch-Morato, M., Guivernau, B., Valls-Comamala, V., Gomis, M., Grau, C., Fandos, C., Rosen, M. D., Rabinowitz, M. H., Inestrosa, N., Maldonado, R., Altafaj, X., Ozaita, A., Alvarez, A., Vicente, R., Valverde, M. A. and Munoz, F. J. (2016). Glutamatergic stimulation induces GluN2B translation by the nitric oxide-Heme-Regulated eIF2alpha kinase in cortical neurons. Oncotarget 7(37): 58876-58892.
6. Busquets-Garcia, A., Gomis-Gonzalez, M., Srivastava, R. K., Cutando, L., Ortega-Alvaro, A., Ruehle, S., Remmers, F., Bindila, L., Bellocchio, L., Marsicano, G., Lutz, B., Maldonado, R. and Ozaita, A. (2016). Peripheral and central CB1 cannabinoid receptors control stress-induced impairment of memory consolidation. Proc Natl Acad Sci U S A 113(35): 9904-9909.
7. Busquets Garcia, A., Soria-Gomez, E., Bellocchio, L. and Marsicano, G. (2016). Cannabinoid receptor type-1: breaking the dogmas. F1000Res 5.
8. Busquets-Garcia, A., Desprez, T., Metna-Laurent, M., Bellocchio, L., Marsicano, G. and Soria-Gomez, E. (2015). Dissecting the cannabinergic control of behavior: The where matters. Bioessays 37(11): 1215-1225.
9. Soria-Gomez, E., Busquets-Garcia, A., Hu, F., Mehidi, A., Cannich, A., Roux, L., Louit, I., Alonso, L., Wiesner, T., Georges, F., Verrier, D., Vincent, P., Ferreira, G., Luo, M. and Marsicano, G. (2015). Habenular CB1 Receptors Control the Expression of Aversive Memories. Neuron 88(2): 306-313.
10. Ill-Raga, G., Tajes, M., Busquets-Garcia, A., Ramos-Fernandez, E., Vargas, L. M., Bosch-Morato, M., Guivernau, B., Valls-Comamala, V., Eraso-Pichot, A., Guix, F. X., Fandos, C., Rosen, M. D., Rabinowitz, M. H., Maldonado, R., Alvarez, A. R., Ozaita, A. and Munoz, F. J. (2015). Physiological Control of Nitric Oxide in Neuronal BACE1 Translation by Heme-Regulated eIF2alpha Kinase HRI Induces Synaptogenesis. Antioxid Redox Signal 22(15): 1295-1307.
11. Busquets-Garcia, A., Maldonado, R. and Ozaita, A. (2014). New insights into the molecular pathophysiology of fragile X syndrome and therapeutic perspectives from the animal model. Int J Biochem Cell Biol 53: 121-126.
12. Busquets-Garcia, A., Gomis-Gonzalez, M., Guegan, T., Agustin-Pavon, C., Pastor, A., Mato, S., Perez-Samartin, A., Matute, C., de la Torre, R., Dierssen, M., Maldonado, R. and Ozaita, A. (2013). Targeting the endocannabinoid system in the treatment of fragile X syndrome. Nat Med 19(5): 603-607.
13. Garcia-Gutierrez, M. S., Ortega-Alvaro, A., Busquets-Garcia, A., Perez-Ortiz, J. M., Caltana, L., Ricatti, M. J., Brusco, A., Maldonado, R. and Manzanares, J. (2013). Synaptic plasticity alterations associated with memory impairment induced by deletion of CB2 cannabinoid receptors. Neuropharmacology 73: 388-396.
14. Cutando, L., Busquets-Garcia, A., Puighermanal, E., Gomis-Gonzalez, M., Delgado-Garcia, J. M., Gruart, A., Maldonado, R. and Ozaita, A. (2013). Microglial activation underlies cerebellar deficits produced by repeated cannabis exposure. J Clin Invest 123(7): 2816-2831.
15. Puighermanal, E., Busquets-Garcia, A., Gomis-Gonzalez, M., Marsicano, G., Maldonado, R. and Ozaita, A. (2013). Dissociation of the pharmacological effects of THC by mTOR blockade. Neuropsychopharmacology 38(7): 1334-1343.
16. Puighermanal, E., Busquets-Garcia, A., Maldonado, R. and Ozaita, A. (2012). Cellular and intracellular mechanisms involved in the cognitive impairment of cannabinoids. Philos Trans R Soc Lond B Biol Sci 367(1607): 3254-3263.
17. Busquets-Garcia, A., Puighermanal, E., Pastor, A., de la Torre, R., Maldonado, R. and Ozaita, A. (2011). Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses. Biol Psychiatry 70(5): 479-486.
18. Puighermanal, E., Marsicano, G., Busquets-Garcia, A., Lutz, B., Maldonado, R. and Ozaita, A. (2009). Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling. Nat Neurosci 12(9): 1152-1158.
19. Comas, D., Schmid, H., Braeuer, S., Flaiz, C., Busquets, A., Calafell, F., Bertranpetit, J., Scheil, H. G., Huckenbeck, W., Efremovska, L. and Schmidt, H. (2004). Alu insertion polymorphisms in the Balkans and the origins of the Aromuns. Ann Hum Genet 68(Pt 2): 120-127.
已发表 protocol 3篇
An Alternative Maze to Assess Novel Object Recognition in Mice
一种评价小鼠新目标识别的替代迷宫

The novel object recognition (NOR) task is a behavioral test commonly used to evaluate episodic-like declarative memory and it relies on the innate tendency of rodents to explore novelty. Here we present a maze used to evaluate NOR memory in mice ...
Assessing Prepulse Inhibition of Startle in Mice
评估小鼠惊吓的前脉冲抑制

作者:Christina Ioannidou, Giovanni Marsicano and Arnau Busquets-Garcia日期:04/05/2018,浏览量:7212,Q&A: 0
Animal models are an important tool for studying neuropsychiatric disorders. However, a major challenge for researchers working with laboratory rodents is trying to reproduce ‘core’ symptoms of complex human disorders such as schizophrenia. Despite ...
参审 protocol 4篇
Assessing Classical Olfactory Fear Conditioning by Behavioral Freezing in Mice
通过小鼠冻结行为检测经典嗅觉条件恐惧
作者:Jordan M. Ross and Max L. Fletcher日期:09/20/2018,浏览量:2719,Q&A: 0
Classical fear conditioning typically involves pairing a discrete cue with a foot shock. Quantifying behavioral freezing to the learned cue is a crucial assay for neuroscience studies focused on learning and memory. Many paradigms utilize discrete ...
查看全文 >
Evaluating Working Memory on a T-maze in Male Rats
评估雄性大鼠对T型迷宫的工作记忆
作者:Ahmed M. Hussein, Mekite Bezu and Volker Korz日期:07/20/2018,浏览量:5628,Q&A: 0
Working memory is short-term memory, so temporal improvement does not reflect the consolidation of a memory trace, rather the functionality of the underlying neuronal circuits and molecular signaling cascades. The administration of drugs–either ...
查看全文 >
主审 protocol 10篇
The Discrete Paired-trial Variable-delay T-maze Task to Assess Working Memory in Mice
利用T迷宫评价小鼠工作记忆的非连续配对变换延迟任务
作者:Gian Marco Leggio, Sebastiano Alfio Torrisi and Francesco Papaleo日期:07/05/2020,浏览量:487,Q&A: 0
Working memory abnormalities involving the prefrontal cortex (PFC) dramatically contribute to poor functional outcomes in patients with schizophrenia and still represent an unmet therapeutic need. Studies in rodents might provide essential tools to ...
查看全文 >
An ex vivo Approach to Assess Mitochondrial ROS by Flow Cytometry in AAV-tagged Astrocytes in Adult Mice
一种利用流式细胞术进行成年大鼠腺相关病毒标记星型胶质细胞中线粒体ROS水平的体外检测方法
作者:Carlos Vicente-Gutierrez and Juan P. Bolaños日期:03/20/2020,浏览量:1027,Q&A: 0
Mitochondrial reactive oxygen species (mROS) are naturally produced signalling molecules extremely relevant for understanding both health- and disease-associated biological processes. The study of mROS in the brain is currently underway to decipher ...
查看全文 >