Education
Ph.D, University of Michigan, USA, 1996
Current position
Associate Professor, Genetic Medicine, Children's National Medical Center, USA
Assistant Professor, Medicine, University of Michigan, USA
Postdoc / Instructor, Molecular Biology, UT Southwestern, USA
Publications
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Zhu, J. Y., Heidersbach, A., Kathiriya, I. S., Garay, B. I., Ivey, K. N., Srivastava, D., Han, Z. and King, I. N. (2017). The E3 ubiquitin ligase Nedd4/Nedd4L is directly regulated by microRNA 1. Development 144(5): 866-875.
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Fu, Y., Zhu, J. Y., Zhang, F., Richman, A., Zhao, Z. and Han, Z. (2017). Comprehensive functional analysis of Rab GTPases in Drosophila nephrocytes. Cell Tissue Res 368(3): 615-627.
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Fu, Y., Zhu, J. Y., Richman, A., Zhao, Z., Zhang, F., Ray, P. E. and Han, Z. (2017). A Drosophila model system to assess the function of human monogenic podocyte mutations that cause nephrotic syndrome. Hum Mol Genet 26(4): 768-780.
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Zhu, J. Y., Fu, Y., Nettleton, M., Richman, A. and Han, Z. (2017). High throughput in vivo functional validation of candidate congenital heart disease genes in Drosophila. Elife 6.
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Zhu, S., Han, Z., Luo, Y., Chen, Y., Zeng, Q., Wu, X. and Yuan, W. (2017). Molecular mechanisms of heart failure: insights from Drosophila. Heart Fail Rev 22(1): 91-98.
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Fu, Y., Zhu, J. Y., Richman, A., Zhang, Y., Xie, X., Das, J. R., Li, J., Ray, P. E. and Han, Z. (2017). APOL1-G1 in Nephrocytes Induces Hypertrophy and Accelerates Cell Death. J Am Soc Nephrol 28(4): 1106-1116.
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Li, J., Das, J. R., Tang, P., Han, Z., Jaiswal, J. K. and Ray, P. E. (2017). Transmembrane TNF-alpha Facilitates HIV-1 Infection of Podocytes Cultured from Children with HIV-Associated Nephropathy. J Am Soc Nephrol 28(3): 862-875.
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Jiang, Z., Li, F., Wan, Y., Han, Z., Yuan, W., Cao, L., Deng, Y., Peng, X., Chen, F., Fan, X., Liu, X., Dai, G., Wang, Y., Zeng, Q., Shi, Y., Zhou, Z., Chen, Y., Xu, W., Luo, S., Chen, S., Ye, X., Mo, X., Wu, X. and Li, Y. (2016). LASS5 Interacts with SDHB and Synergistically Represses p53 and p21 Activity. Curr Mol Med 16(6): 582-590.
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Patel, M. V., Zhu, J. Y., Jiang, Z., Richman, A., VanBerkum, M. F. and Han, Z. (2016). Gia/Mthl5 is an aorta specific GPCR required for Drosophila heart tube morphology and normal pericardial cell positioning. Dev Biol 414(1): 100-107.
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Chen, Z., Zhu, J. Y., Fu, Y., Richman, A. and Han, Z. (2016). Wnt4 is required for ostia development in the Drosophila heart. Dev Biol 413(2): 188-198.
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Fulga, T. A., McNeill, E. M., Binari, R., Yelick, J., Blanche, A., Booker, M., Steinkraus, B. R., Schnall-Levin, M., Zhao, Y., DeLuca, T., Bejarano, F., Han, Z., Lai, E. C., Wall, D. P., Perrimon, N. and Van Vactor, D. (2015). A transgenic resource for conditional competitive inhibition of conserved Drosophila microRNAs. Nat Commun 6: 7279.
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Gee, H. Y., Zhang, F., Ashraf, S., Kohl, S., Sadowski, C. E., Vega-Warner, V., Zhou, W., Lovric, S., Fang, H., Nettleton, M., Zhu, J. Y., Hoefele, J., Weber, L. T., Podracka, L., Boor, A., Fehrenbach, H., Innis, J. W., Washburn, J., Levy, S., Lifton, R. P., Otto, E. A., Han, Z. and Hildebrandt, F. (2015). KANK deficiency leads to podocyte dysfunction and nephrotic syndrome. J Clin Invest 125(6): 2375-2384.
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Ashraf, S., Gee, H. Y., Woerner, S., Xie, L. X., Vega-Warner, V., Lovric, S., Fang, H., Song, X., Cattran, D. C., Avila-Casado, C., Paterson, A. D., Nitschke, P., Bole-Feysot, C., Cochat, P., Esteve-Rudd, J., Haberberger, B., Allen, S. J., Zhou, W., Airik, R., Otto, E. A., Barua, M., Al-Hamed, M. H., Kari, J. A., Evans, J., Bierzynska, A., Saleem, M. A., Bockenhauer, D., Kleta, R., El Desoky, S., Hacihamdioglu, D. O., Gok, F., Washburn, J., Wiggins, R. C., Choi, M., Lifton, R. P., Levy, S., Han, Z., Salviati, L., Prokisch, H., Williams, D. S., Pollak, M., Clarke, C. F., Pei, Y., Antignac, C. and Hildebrandt, F. (2013). ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption. J Clin Invest 123(12): 5179-5189.
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Gee, H. Y., Saisawat, P., Ashraf, S., Hurd, T. W., Vega-Warner, V., Fang, H., Beck, B. B., Gribouval, O., Zhou, W., Diaz, K. A., Natarajan, S., Wiggins, R. C., Lovric, S., Chernin, G., Schoeb, D. S., Ovunc, B., Frishberg, Y., Soliman, N. A., Fathy, H. M., Goebel, H., Hoefele, J., Weber, L. T., Innis, J. W., Faul, C., Han, Z., Washburn, J., Antignac, C., Levy, S., Otto, E. A. and Hildebrandt, F. (2013). ARHGDIA mutations cause nephrotic syndrome via defective RHO GTPase signaling. J Clin Invest 123(8): 3243-3253.
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Zhang, F., Zhao, Y., Chao, Y., Muir, K. and Han, Z. (2013). Cubilin and amnionless mediate protein reabsorption in Drosophila nephrocytes. J Am Soc Nephrol 24(2): 209-216.
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Zhang, F., Zhao, Y. and Han, Z. (2013). An in vivo functional analysis system for renal gene discovery in Drosophila pericardial nephrocytes. J Am Soc Nephrol 24(2): 191-197.
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Chen, Z., Liang, S., Zhao, Y. and Han, Z. (2012). miR-92b regulates Mef2 levels through a negative-feedback circuit during Drosophila muscle development. Development 139(19): 3543-3552.
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Yi, P., Johnson, A. N., Han, Z., Wu, J. and Olson, E. N. (2008). Heterotrimeric G proteins regulate a noncanonical function of septate junction proteins to maintain cardiac integrity in Drosophila. Dev Cell 15(5): 704-713.
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Elalayli, M., Hall, J. D., Fakhouri, M., Neiswender, H., Ellison, T. T., Han, Z., Roon, P. and LeMosy, E. K. (2008). Palisade is required in the Drosophila ovary for assembly and function of the protective vitelline membrane. Dev Biol 319(2): 359-369.
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Liu, J., Qian, L., Han, Z., Wu, X. and Bodmer, R. (2008). Spatial specificity of mesodermal even-skipped expression relies on multiple repressor sites. Dev Biol 313(2): 876-886.
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Liotta, D., Han, J., Elgar, S., Garvey, C., Han, Z. and Taylor, M. V. (2007). The Him gene reveals a balance of inputs controlling muscle differentiation in Drosophila. Curr Biol 17(16): 1409-1413.
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Yi, P., Han, Z., Li, X. and Olson, E. N. (2006). The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Ggamma1. Science 313(5791): 1301-1303.
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Han, Z., Yi, P., Li, X. and Olson, E. N. (2006). Hand, an evolutionarily conserved bHLH transcription factor required for Drosophila cardiogenesis and hematopoiesis. Development 133(6): 1175-1182.
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Kwon, C., Han, Z., Olson, E. N. and Srivastava, D. (2005). MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling. Proc Natl Acad Sci U S A 102(52): 18986-18991.
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Fujioka, M., Wessells, R. J., Han, Z., Liu, J., Fitzgerald, K., Yusibova, G. L., Zamora, M., Ruiz-Lozano, P., Bodmer, R. and Jaynes, J. B. (2005). Embryonic even skipped-dependent muscle and heart cell fates are required for normal adult activity, heart function, and lifespan. Circ Res 97(11): 1108-1114.
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Han, Z. and Olson, E. N. (2005). Hand is a direct target of Tinman and GATA factors during Drosophila cardiogenesis and hematopoiesis. Development 132(15): 3525-3536.
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Han, Z., Li, X., Wu, J. and Olson, E. N. (2004). A myocardin-related transcription factor regulates activity of serum response factor in Drosophila. Proc Natl Acad Sci U S A 101(34): 12567-12572.
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Han, Z. and Bodmer, R. (2003). Myogenic cells fates are antagonized by Notch only in asymmetric lineages of the Drosophila heart, with or without cell division. Development 130(13): 3039-3051.
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Han, Z. (2002). Genetic control of cardiac cell type specification in Drosophila. Dissertation.
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Han, Z., Fujioka, M., Su, M., Liu, M., Jaynes, J. B. and Bodmer, R. (2002). Transcriptional integration of competence modulated by mutual repression generates cell-type specificity within the cardiogenic mesoderm. Dev Biol 252(2): 225-240.