Education

Ph.D. in Physical Organic Chemistry, University of Chicago, 1968

Current position

SUNY Distinguished Professor, Biochemistry, Jacobs School of Medicine and Biomedical Sciences

Publications (since 2011)

1. Bailao, E. F., Lima Pde, S., Silva-Bailao, M. G., Bailao, A. M., Fernandes Gda, R., Kosman, D. J. and Soares, C. M. (2015). Paracoccidioides spp. ferrous and ferric iron assimilation pathways. Front Microbiol 6: 821.

2. Ji, C. and Kosman, D. J. (2015). Molecular mechanisms of non-transferrin-bound and transferring-bound iron uptake in primary hippocampal neurons. J Neurochem 133(5): 668-683.

3. McCarthy, R. C. and Kosman, D. J. (2015). Mechanisms and regulation of iron trafficking across the capillary endothelial cells of the blood-brain barrier. Front Mol Neurosci 8: 31.

4. McCarthy, R. C. and Kosman, D. J. (2015). Iron transport across the blood-brain barrier: development, neurovascular regulation and cerebral amyloid angiopathy. Cell Mol Life Sci 72(4): 709-727.

5. McCarthy, R. C., Park, Y. H. and Kosman, D. J. (2014). sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin. EMBO Rep 15(7): 809-815.

6. McCarthy, R. C. and Kosman, D. J. (2014). Activation of C6 glioblastoma cell ceruloplasmin expression by neighboring human brain endothelia-derived interleukins in an in vitro blood-brain barrier model system. Cell Commun Signal 12: 65.

7. McCarthy, R. C. and Kosman, D. J. (2014). Glial cell ceruloplasmin and hepcidin differentially regulate iron efflux from brain microvascular endothelial cells. PLoS One 9(2): e89003.

8. Kjaergaard, C. H., Qayyum, M. F., Augustine, A. J., Ziegler, L., Kosman, D. J., Hodgson, K. O., Hedman, B. and Solomon, E. I. (2013). Modified reactivity toward O2 in first shell variants of Fet3p: geometric and electronic structure requirements for a functioning trinuclear copper cluster. Biochemistry 52(21): 3702-3711.

9. McCarthy, R. C. and Kosman, D. J. (2013). Ferroportin and exocytoplasmic ferroxidase activity are required for brain microvascular endothelial cell iron efflux. J Biol Chem 288(24): 17932-17940.

10. Kosman, D. J. (2013). Iron metabolism in aerobes: managing ferric iron hydrolysis and ferrous iron autoxidation. Coord Chem Rev 257(1): 210-217.

11. McCarthy, R. C. and Kosman, D. J. (2012). Mechanistic analysis of iron accumulation by endothelial cells of the BBB. Biometals 25(4): 665-675.

12. Kosman, D. J. (2011). Transport: Plutonium's Trojan horse. Nat Chem Biol 7(8): 498-499.

13. Ziegler, L., Terzulli, A., Gaur, R., McCarthy, R. and Kosman, D. J. (2011). Functional characterization of the ferroxidase, permease high-affinity iron transport complex from Candida albicans. Mol Microbiol 81(2): 473-485.