EJ
Eun-Kyeong Jo
  • Department of Microbiology, Chungnam National University School of Medicine, S. Korea
研究方向
  • Immunology
个人信息

Education

Ph.D. in Department of Microbiology, College of Medicine, CNU, Korea, 1996

Current position

Professor, Dept. of Microbiology, College of Medicine, CNU (2008-present)
Director, Medical Research Center (ISNRC), CNU (2007-present)

Publications (selected)

  1. Yuk, J. M., Kim, T. S., Kim, S. Y., Lee, H. M., Han, J., Dufour, C. R., Kim, J. K., Jin, H. S., Yang, C. S., Park, K. S., Lee, C. H., Kim, J. M., Kweon, G. R., Choi, H. S., Vanacker, J. M., Moore, D. D., Giguere, V. and Jo, E. K.* (2015). Orphan Nuclear Receptor ERRα Controls Macrophage Metabolic Signaling and A20 Expression to Negatively Regulate TLR-Induced Inflammation. Immunity 43(1): 80-91.
  2. Yang, C. S., Kim, J. J., Kim, T. S., Lee, P. Y., Kim, S. Y., Lee, H. M., Shin, D. M., Nguyen, L. T., Lee, M. S., Jin, H. S., Kim, K. K., Lee, C. H., Kim, M. H., Park, S. G., Kim, J. M., Choi, H. S. and Jo, E. K.* (2015). Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome. Nat Commun 6: 6115.
  3. Kim, J. K., Yuk, J. M., Kim, S. Y., Kim, T. S., Jin, H. S., Yang, C. S. and Jo, E. K.* (2015). MicroRNA-125a Inhibits Autophagy Activation and Antimicrobial Responses during Mycobacterial Infection. J Immunol 194(11): 5355-5365.
  4. Yang, C. S., Kim, J. J., Lee, H. M., Jin, H. S., Lee, S. H., Park, J. H., Kim, S. J., Kim, J. M., Han, Y. M., Lee, M. S., Kweon, G. R., Shong, M. and Jo, E. K.* (2014). The AMPK-PPARGC1A pathway is required for antimicrobial host defense through activation of autophagy. Autophagy 10(5): 785-802.
  5. Lee, H. M., Kim, J. J., Kim, H. J., Shong, M., Ku, B. J. and Jo, E. K.* (2013). Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes. Diabetes 62(1): 194-204.
  6. Kim, J. J., Lee, H. M., Shin, D. M., Kim, W., Yuk, J. M., Jin, H. S., Lee, S. H., Cha, G. H., Kim, J. M., Lee, Z. W., Shin, S. J., Yoo, H., Park, Y. K., Park, J. B., Chung, J., Yoshimori, T. and Jo, E. K.* (2012). Host cell autophagy activated by antibiotics is required for their effective antimycobacterial drug action. Cell Host Microbe 11(5): 457-468.
  7. Kim, K. H., An, D. R., Song, J., Yoon, J. Y., Kim, H. S., Yoon, H. J., Im, H. N., Kim, J., Kim do, J., Lee, S. J., Kim, K. H., Lee, H. M., Kim, H. J., Jo, E. K., Lee, J. Y. and Suh, S. W. (2012). Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation of DUSP16/MKP-7. Proc Natl Acad Sci U S A 109(20): 7729-7734.
  8. Yuk, J. M., Shin, D. M., Lee, H. M., Kim, J. J., Kim, S. W., Jin, H. S., Yang, C. S., Park, K. A., Chanda, D., Kim, D. K., Huang, S. M., Lee, S. K., Lee, C. H., Kim, J. M., Song, C. H., Lee, S. Y., Hur, G. M., Moore, D. D., Choi, H. S. and Jo, E. K.* (2011). The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptors. Nat Immunol 12(8): 742-751.
  9. Fabri, M., Stenger, S., Shin, D. M., Yuk, J. M., Liu, P. T., Realegeno, S., Lee, H. M., Krutzik, S. R., Schenk, M., Sieling, P. A., Teles, R., Montoya, D., Iyer, S. S., Bruns, H., Lewinsohn, D. M., Hollis, B. W., Hewison, M., Adams, J. S., Steinmeyer, A., Zugel, U., Cheng, G., Jo, E. K., Bloom, B. R. and Modlin, R. L. (2011). Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages. Sci Transl Med 3(104): 104ra102.
  10. Lee, H. M., Shin, D. M., Yuk, J. M., Shi, G., Choi, D. K., Lee, S. H., Huang, S. M., Kim, J. M., Kim, C. D., Lee, J. H. and Jo, E. K.* (2011). Autophagy negatively regulates keratinocyte inflammatory responses via scaffolding protein p62/SQSTM1. J Immunol 186(2): 1248-1258.
  11. Fabri, M., Realegeno, S. E., Jo, E. K. and Modlin, R. L. (2011). Role of autophagy in the host response to microbial infection and potential for therapy. Curr Opin Immunol 23(1): 65-70.
  12. Shin, D. M., Jeon, B. Y., Lee, H. M., Jin, H. S., Yuk, J. M., Song, C. H., Lee, S. H., Lee, Z. W., Cho, S. N., Kim, J. M., Friedman, R. L. and Jo, E. K.* (2010). Mycobacterium tuberculosis eis regulates autophagy, inflammation, and cell death through redox-dependent signaling. PLoS Pathog 6(12): e1001230.
  13. Jo, E. K.* (2010). Innate immunity to mycobacteria: vitamin D and autophagy. Cell Microbiol 12(8): 1026-1035.
  14. Yuk, J. M., Shin, D. M., Song, K. S., Lim, K., Kim, K. H., Lee, S. H., Kim, J. M., Lee, J. S., Paik, T. H., Kim, J. S. and Jo, E. K.* (2010). Bacillus calmette-guerin cell wall cytoskeleton enhances colon cancer radiosensitivity through autophagy. Autophagy 6(1): 46-60.
  15. Kim, D., You, B., Jo, E. K., Han, S. K., Simon, M. I. and Lee, S. J. (2010). NADPH oxidase 2-derived reactive oxygen species in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain. Proc Natl Acad Sci U S A 107(33): 14851-14856.
  16. Lee, H. M., Yuk, J. M., Shin, D. M., Yang, C. S., Kim, K. K., Choi, D. K., Liang, Z. L., Kim, J. M., Jeon, B. H., Kim, C. D., Lee, J. H. and Jo, E. K.* (2009). Apurinic/apyrimidinic endonuclease 1 is a key modulator of keratinocyte inflammatory responses. J Immunol 183(10): 6839-6848.
  17. Yuk, J. M., Shin, D. M., Lee, H. M., Yang, C. S., Jin, H. S., Kim, K. K., Lee, Z. W., Lee, S. H., Kim, J. M. and Jo, E. K.* (2009). Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin. Cell Host Microbe 6(3): 231-243.
  18. Yuk, J. M., Yang, C. S., Shin, D. M., Kim, K. K., Lee, S. K., Song, Y. J., Lee, H. M., Cho, C. H., Jeon, B. H. and Jo, E. K.* (2009). A dual regulatory role of apurinic/apyrimidinic endonuclease 1/redox factor-1 in HMGB1-induced inflammatory responses. Antioxid Redox Signal 11(3): 575-588.
  19. Jo, E. K.* (2008). Mycobacterial interaction with innate receptors: TLRs, C-type lectins, and NLRs. Curr Opin Infect Dis 21(3): 279-286.
  20. Yang, C. S., Lee, D. S., Song, C. H., An, S. J., Li, S., Kim, J. M., Kim, C. S., Yoo, D. G., Jeon, B. H., Yang, H. Y., Lee, T. H., Lee, Z. W., El-Benna, J., Yu, D. Y. and Jo, E. K.* (2007). Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock. J Exp Med 204(3): 583-594.