BF
B. Brett Finlay
  • Michael Smith Laboratories, University of British Columbia, Canada
研究方向
  • Microbiology
个人信息

Education

Ph.D. in Biochemistry, the University of Alberta, 1986

Current position

Professor in the Michael Smith Laboratories, and the Departments of Biochemistry and Molecular Biology, and Microbiology and Immunology at the University of British Columbia

Publications (since 2011)

  1. Croxen, M. A., Law, R. J., Scholz, R., Keeney, K. M., Wlodarska, M. and Finlay, B. B. (2013). Recent advances in understanding enteric pathogenic Escherichia coli. Clin Microbiol Rev 26(4): 822-880.
  2. Amaral, J. J., Antunes, L. C., de Macedo, C. S., Mattos, K. A., Han, J., Pan, J., Candea, A. L., Henriques, M., Ribeiro-Alves, M., Borchers, C. H., Sarno, E. N., Bozza, P. T., Finlay, B. B. and Pessolani, M. C. (2013). Metabonomics reveals drastic changes in anti-inflammatory/pro-resolving polyunsaturated fatty acids-derived lipid mediators in leprosy disease. PLoS Negl Trop Dis 7(8): e2381.
  3. Marchiando, A. M., Ramanan, D., Ding, Y., Gomez, L. E., Hubbard-Lucey, V. M., Maurer, K., Wang, C., Ziel, J. W., van Rooijen, N., Nunez, G., Finlay, B. B., Mysorekar, I. U. and Cadwell, K. (2013). A deficiency in the autophagy gene Atg16L1 enhances resistance to enteric bacterial infection. Cell Host Microbe 14(2): 216-224.
  4. Bhavsar, A. P., Brown, N. F., Stoepel, J., Wiermer, M., Martin, D. D., Hsu, K. J., Imami, K., Ross, C. J., Hayden, M. R., Foster, L. J., Li, X., Hieter, P. and Finlay, B. B. (2013). The Salmonella type III effector SspH2 specifically exploits the NLR co-chaperone activity of SGT1 to subvert immunity. PLoS Pathog 9(7): e1003518.
  5. Buckner, M. M., Antunes, L. C., Gill, N., Russell, S. L., Shames, S. R. and Finlay, B. B. (2013). 15-Deoxy-Delta12,14-prostaglandin J2 inhibits macrophage colonization by Salmonella enterica serovar Typhimurium. PLoS One 8(7): e69759.
  6. Donnenberg, M. S. and Finlay, B. B. (2013). Combating enteropathogenic Escherichia coli (EPEC) infections: the way forward. Trends Microbiol 21(7): 317-319.
  7. Brown, E. M., Sadarangani, M. and Finlay, B. B. (2013). The role of the immune system in governing host-microbe interactions in the intestine. Nat Immunol 14(7): 660-667.
  8. Sal-Man, N., Setiaputra, D., Scholz, R., Deng, W., Yu, A. C., Strynadka, N. C. and Finlay, B. B. (2013). EscE and EscG are cochaperones for the type III needle protein EscF of enteropathogenic Escherichia coli. J Bacteriol 195(11): 2481-2489.
  9. Imami, K., Bhavsar, A. P., Yu, H., Brown, N. F., Rogers, L. D., Finlay, B. B. and Foster, L. J. (2013). Global impact of Salmonella pathogenicity island 2-secreted effectors on the host phosphoproteome. Mol Cell Proteomics 12(6): 1632-1643.
  10. Law, R. J., Gur-Arie, L., Rosenshine, I. and Finlay, B. B. (2013). In vitro and in vivo model systems for studying enteropathogenic Escherichia coli infections. Cold Spring Harb Perspect Med 3(3): a009977.
  11. Olsen, R. L., Echtenkamp, F., Cheranova, D., Deng, W., Finlay, B. B. and Hardwidge, P. R. (2013). The enterohemorrhagic Escherichia coli effector protein NleF binds mammalian Tmp21. Vet Microbiol 164(1-2): 164-170.
  12. Keeney, K. M. and Finlay, B. B. (2013). Microbiology: EHEC downregulates virulence in response to intestinal fucose. Curr Biol 23(3): R108-110.
  13. Backhed, F., Fraser, C. M., Ringel, Y., Sanders, M. E., Sartor, R. B., Sherman, P. M., Versalovic, J., Young, V. and Finlay, B. B. (2012). Defining a healthy human gut microbiome: current concepts, future directions, and clinical applications. Cell Host Microbe 12(5): 611-622.
  14. Gill, N., Ferreira, R. B., Antunes, L. C., Willing, B. P., Sekirov, I., Al-Zahrani, F., Hartmann, M. and Finlay, B. B. (2012). Neutrophil elastase alters the murine gut microbiota resulting in enhanced Salmonella colonization. PLoS One 7(11): e49646.
  15. Kumar, N. S., Amandoron, E. A., Cherkasov, A., Finlay, B. B., Gong, H., Jackson, L., Kaur, S., Lian, T., Moreau, A., Labriere, C., Reiner, N. E., See, R. H., Strynadka, N. C., Thorson, L., Wong, E. W., Worrall, L., Zoraghi, R. and Young, R. N. (2012). Optimization and structure-activity relationships of a series of potent inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as novel antimicrobial agents. Bioorg Med Chem 20(24): 7069-7082.
  16. Menendez, A., Willing, B. P., Montero, M., Wlodarska, M., So, C. C., Bhinder, G., Vallance, B. A. and Finlay, B. B. (2013). Bacterial stimulation of the TLR-MyD88 pathway modulates the homeostatic expression of ileal Paneth cell alpha-defensins. J Innate Immun 5(1): 39-49.
  17. Karch, H., Denamur, E., Dobrindt, U., Finlay, B. B., Hengge, R., Johannes, L., Ron, E. Z., Tonjum, T., Sansonetti, P. J. and Vicente, M. (2012). The enemy within us: lessons from the 2011 European Escherichia coli O104:H4 outbreak. EMBO Mol Med 4(9): 841-848.
  18. Prehna, G., Li, Y., Stoynov, N., Okon, M., Vuckovic, M., McIntosh, L. P., Foster, L. J., Finlay, B. B. and Strynadka, N. C. (2012). The zinc regulated antivirulence pathway of Salmonella is a multiprotein immunoglobulin adhesion system. J Biol Chem 287(39): 32324-32337.
  19. Cortes-Vieyra, R., Bravo-Patino, A., Valdez-Alarcon, J. J., Juarez, M. C., Finlay, B. B. and Baizabal-Aguirre, V. M. (2012). Role of glycogen synthase kinase-3 beta in the inflammatory response caused by bacterial pathogens. J Inflamm (Lond) 9(1): 23.
  20. Russell, S. L. and Finlay, B. B. (2012). The impact of gut microbes in allergic diseases. Curr Opin Gastroenterol 28(6): 563-569. (Review)
  21. Deng, W., Yu, H. B., de Hoog, C. L., Stoynov, N., Li, Y., Foster, L. J. and Finlay, B. B. (2012). Quantitative proteomic analysis of type III secretome of enteropathogenic Escherichia coli reveals an expanded effector repertoire for attaching/effacing bacterial pathogens. Mol Cell Proteomics 11(9): 692-709.
  22. van der Heijden, J. and Finlay, B. B. (2012). Type III effector-mediated processes in Salmonella infection. Future Microbiol 7(6): 685-703.
  23. Arrieta, M. C. and Finlay, B. B. (2012). The commensal microbiota drives immune homeostasis. Front Immunol 3: 33.
  24. Achtman, A. H., Pilat, S., Law, C. W., Lynn, D. J., Janot, L., Mayer, M. L., Ma, S., Kindrachuk, J., Finlay, B. B., Brinkman, F. S., Smyth, G. K., Hancock, R. E. and Schofield, L. (2012). Effective adjunctive therapy by an innate defense regulatory peptide in a preclinical model of severe malaria. Sci Transl Med 4(135): 135ra164.
  25. Liu, Z., Zaki, M. H., Vogel, P., Gurung, P., Finlay, B. B., Deng, W., Lamkanfi, M. and Kanneganti, T. D. (2012). Role of inflammasomes in host defense against Citrobacter rodentium infection. J Biol Chem 287(20): 16955-16964.
  26. Sal-Man, N., Biemans-Oldehinkel, E., Sharon, D., Croxen, M. A., Scholz, R., Foster, L. J. and Finlay, B. B. (2012). EscA is a crucial component of the type III secretion system of enteropathogenic Escherichia coli. J Bacteriol 194(11): 2819-2828.
  27. Shames, S. R. and Finlay, B. B. (2012). Bacterial effector interplay: a new way to view effector function. Trends Microbiol 20(5): 214-219.
  28. Russell, S. L., Gold, M. J., Hartmann, M., Willing, B. P., Thorson, L., Wlodarska, M., Gill, N., Blanchet, M. R., Mohn, W. W., McNagny, K. M. and Finlay, B. B. (2012). Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma. EMBO Rep 13(5): 440-447.
  29. Ferreira, R. B. and Finlay, B. B. (2012). Identifying an immune signature against invasive Salmonella. Proc Natl Acad Sci U S A 109(13): 4721-4722.
  30. Antunes, L. C., Wang, M., Andersen, S. K., Ferreira, R. B., Kappelhoff, R., Han, J., Borchers, C. H. and Finlay, B. B. (2012). Repression of Salmonella enterica phoP expression by small molecules from physiological bile. J Bacteriol 194(9): 2286-2296.
  31. Sal-Man, N., Deng, W. and Finlay, B. B. (2012). EscI: a crucial component of the type III secretion system forms the inner rod structure in enteropathogenic Escherichia coli. Biochem J 442(1): 119-125.
  32. Axerio-Cilies, P., See, R. H., Zoraghi, R., Worral, L., Lian, T., Stoynov, N., Jiang, J., Kaur, S., Jackson, L., Gong, H., Swayze, R., Amandoron, E., Kumar, N. S., Moreau, A., Hsing, M., Strynadka, N. C., McMaster, W. R., Finlay, B. B., Foster, L. J., Young, R. N., Reiner, N. E. and Cherkasov, A. (2012). Cheminformatics-driven discovery of selective, nanomolar inhibitors for staphylococcal pyruvate kinase. ACS Chem Biol 7(2): 350-359.
  33. Willing, B. P., Vacharaksa, A., Croxen, M., Thanachayanont, T. and Finlay, B. B. (2011). Altering host resistance to infections through microbial transplantation. PLoS One 6(10): e26988.
  34. Zoraghi, R., Worrall, L., See, R. H., Strangman, W., Popplewell, W. L., Gong, H., Samaai, T., Swayze, R. D., Kaur, S., Vuckovic, M., Finlay, B. B., Brunham, R. C., McMaster, W. R., Davies-Coleman, M. T., Strynadka, N. C., Andersen, R. J. and Reiner, N. E. (2011). Methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as a target for bis-indole alkaloids with antibacterial activities. J Biol Chem 286(52): 44716-44725.
  35. Brown, N. F. and Finlay, B. B. (2011). Potential origins and horizontal transfer of type III secretion systems and effectors. Mob Genet Elements 1(2): 118-121.
  36. Auweter, S. D., Yu, H. B., Arena, E. T., Guttman, J. A. and Finlay, B. B. (2012). Oxysterol-binding protein (OSBP) enhances replication of intracellular Salmonella and binds the Salmonella SPI-2 effector SseL via its N-terminus. Microbes Infect 14(2): 148-154.
  37. Shames, S. R., Croxen, M. A., Deng, W. and Finlay, B. B. (2011). The type III system-secreted effector EspZ localizes to host mitochondria and interacts with the translocase of inner mitochondrial membrane 17b. Infect Immun 79(12): 4784-4790.
  38. Schreiber, F., Lynn, D. J., Houston, A., Peters, J., Mwafulirwa, G., Finlay, B. B., Brinkman, F. S., Hancock, R. E., Heyderman, R. S., Dougan, G. and Gordon, M. A. (2011). The human transcriptome during nontyphoid Salmonella and HIV coinfection reveals attenuated NFkappaB-mediated inflammation and persistent cell cycle disruption. J Infect Dis 204(8): 1237-1245.
  39. Shames, S. R. and Finlay, B. B. (2011). Proteolytic Cleavage of NF-kappaB p65: A Novel Mechanism for Subversion of Innate Immune Signaling by Pathogenic E. Coli. Front Microbiol 2: 38.
  40. Arena, E. T., Auweter, S. D., Antunes, L. C., Vogl, A. W., Han, J., Guttman, J. A., Croxen, M. A., Menendez, A., Covey, S. D., Borchers, C. H. and Finlay, B. B. (2011). The deubiquitinase activity of the Salmonella pathogenicity island 2 effector, SseL, prevents accumulation of cellular lipid droplets. Infect Immun 79(11): 4392-4400.
  41. Gill, N. and Finlay, B. B. (2011). The gut microbiota: challenging immunology. Nat Rev Immunol 11(10): 636-637.
  42. Oviedo-Boyso, J., Cortes-Vieyra, R., Huante-Mendoza, A., Yu, H. B., Valdez-Alarcon, J. J., Bravo-Patino, A., Cajero-Juarez, M., Finlay, B. B. and Baizabal-Aguirre, V. M. (2011). The phosphoinositide-3-kinase-Akt signaling pathway is important for Staphylococcus aureus internalization by endothelial cells. Infect Immun 79(11): 4569-4577.
  43. Shames, S. R., Bhavsar, A. P., Croxen, M. A., Law, R. J., Mak, S. H., Deng, W., Li, Y., Bidshari, R., de Hoog, C. L., Foster, L. J. and Finlay, B. B. (2011). The pathogenic Escherichia coli type III secreted protease NleC degrades the host acetyltransferase p300. Cell Microbiol 13(10): 1542-1557.
  44. Biemans-Oldehinkel, E., Sal-Man, N., Deng, W., Foster, L. J. and Finlay, B. B. (2011). Quantitative proteomic analysis reveals formation of an EscL-EscQ-EscN type III complex in enteropathogenic Escherichia coli. J Bacteriol 193(19): 5514-5519.
  45. Antunes, L. C., Andersen, S. K., Menendez, A., Arena, E. T., Han, J., Ferreira, R. B., Borchers, C. H. and Finlay, B. B. (2011). Metabolomics reveals phospholipids as important nutrient sources during Salmonella growth in bile in vitro and in vivo. J Bacteriol 193(18): 4719-4725.
  46. Sham, H. P., Shames, S. R., Croxen, M. A., Ma, C., Chan, J. M., Khan, M. A., Wickham, M. E., Deng, W., Finlay, B. B. and Vallance, B. A. (2011). Attaching and effacing bacterial effector NleC suppresses epithelial inflammatory responses by inhibiting NF-kappaB and p38 mitogen-activated protein kinase activation. Infect Immun 79(9): 3552-3562.
  47. Allen, K. J., Rogan, D., Finlay, B. B., Potter, A. A. and Asper, D. J. (2011). Vaccination with type III secreted proteins leads to decreased shedding in calves after experimental infection with Escherichia coli O157. Can J Vet Res 75(2): 98-105.
  48. Buckner, M. M., Croxen, M. A., Arena, E. T. and Finlay, B. B. (2011). A comprehensive study of the contribution of Salmonella enterica serovar Typhimurium SPI2 effectors to bacterial colonization, survival, and replication in typhoid fever, macrophage, and epithelial cell infection models. Virulence 2(3): 208-216.
  49. Ferreira, R. B., Willing, B. P. and Finlay, B. B. (2011). Bringing Koch's postulates to the table in IBD. Cell Host Microbe 9(5): 353-354.
  50. Gal-Mor, O., Elhadad, D., Deng, W., Rahav, G. and Finlay, B. B. (2011). The Salmonella enterica PhoP directly activates the horizontally acquired SPI-2 gene sseL and is functionally different from a S. bongori ortholog. PLoS One 6(5): e20024.
  51. Auweter, S. D., Bhavsar, A. P., de Hoog, C. L., Li, Y., Chan, Y. A., van der Heijden, J., Lowden, M. J., Coombes, B. K., Rogers, L. D., Stoynov, N., Foster, L. J. and Finlay, B. B. (2011). Quantitative mass spectrometry catalogues Salmonella pathogenicity island-2 effectors and identifies their cognate host binding partners. J Biol Chem 286(27): 24023-24035.
  52. Kum, W. W., Lo, B. C., Yu, H. B. and Finlay, B. B. (2011). Protective role of Akt2 in Salmonella enterica serovar typhimurium-induced gastroenterocolitis. Infect Immun 79(7): 2554-2566.
  53. Buckner, M. M. and Finlay, B. B. (2011). Host-microbe interaction: Innate immunity cues virulence. Nature 472(7342): 179-180.
  54. Antunes, L. C. and Finlay, B. B. (2011). A comparative analysis of the effect of antibiotic treatment and enteric infection on intestinal homeostasis. Gut Microbes 2(2): 105-108.
  55. Sal-Man, N., Croxen, M. A. and Finlay, B. B. (2011). Translocation of effectors: revisiting the injectosome model. Future Microbiol 6(5): 483-484.
  56. Brown, N. F., Coombes, B. K., Bishop, J. L., Wickham, M. E., Lowden, M. J., Gal-Mor, O., Goode, D. L., Boyle, E. C., Sanderson, K. L. and Finlay, B. B. (2011). Salmonella phage ST64B encodes a member of the SseK/NleB effector family. PLoS One 6(3): e17824.
  57. Willing, B. P., Antunes, L. C., Keeney, K. M., Ferreira, R. B. and Finlay, B. B. (2011). Harvesting the biological potential of the human gut microbiome. Bioessays 33(6): 414-418.
  58. Shames, S. R. and Finlay, B. B. (2011). Proteolytic Cleavage of NF-kappaB p65: A Novel Mechanism for Subversion of Innate Immune Signaling by Pathogenic E. Coli. Front Microbiol 2: 38.
  59. Antunes, L. C., Davies, J. E. and Finlay, B. B. (2011). Chemical signaling in the gastrointestinal tract. F1000 Biol Rep 3: 4.
  60. Gill, N., Wlodarska, M. and Finlay, B. B. (2011). Roadblocks in the gut: barriers to enteric infection. Cell Microbiol 13(5): 660-669.
  61. Willing, B. P., Russell, S. L. and Finlay, B. B. (2011). Shifting the balance: antibiotic effects on host-microbiota mutualism. Nat Rev Microbiol 9(4): 233-243.
  62. Zoraghi, R., See, R. H., Axerio-Cilies, P., Kumar, N. S., Gong, H., Moreau, A., Hsing, M., Kaur, S., Swayze, R. D., Worrall, L., Amandoron, E., Lian, T., Jackson, L., Jiang, J., Thorson, L., Labriere, C., Foster, L., Brunham, R. C., McMaster, W. R., Finlay, B. B., Strynadka, N. C., Cherkasov, A., Young, R. N. and Reiner, N. E. (2011). Identification of pyruvate kinase in methicillin-resistant Staphylococcus aureus as a novel antimicrobial drug target. Antimicrob Agents Chemother 55(5): 2042-2053.
  63. Antunes, L. C., Arena, E. T., Menendez, A., Han, J., Ferreira, R. B., Buckner, M. M., Lolic, P., Madilao, L. L., Bohlmann, J., Borchers, C. H. and Finlay, B. B. (2011). Impact of salmonella infection on host hormone metabolism revealed by metabolomics. Infect Immun 79(4): 1759-1769.
  64. Antunes, L. C., Arena, E. T., Menendez, A., Han, J., Ferreira, R. B., Buckner, M. M., Lolic, P., Madilao, L. L., Bohlmann, J., Borchers, C. H. and Finlay, B. B. (2011). Impact of salmonella infection on host hormone metabolism revealed by metabolomics. Infect Immun 79(4): 1759-1769.
  65. Antunes, L. C., Han, J., Ferreira, R. B., Lolic, P., Borchers, C. H. and Finlay, B. B. (2011). Effect of antibiotic treatment on the intestinal metabolome. Antimicrob Agents Chemother 55(4): 1494-1503.
  66. Antunes, L. C. M., Davies, J. E. and Finlay, B. B. (2011). Mining bacterial small molecules. Scientist 25: 26-30.
  67. Finlay, B. B. and Bonas, U. (2011). Host-microbe interactions: ever increasing complexity. Curr Opin Microbiol 14(1): 1-2.
  68. Tourret, J. and Finlay, B. B. (2011). A receptor for meningococcus: eliciting beta-arrestin signaling for barrier breaching. Dev Cell 20(1): 7-8.
  69. Keeney, K. M. and Finlay, B. B. (2011). Enteric pathogen exploitation of the microbiota-generated nutrient environment of the gut. Curr Opin Microbiol 14(1): 92-98.
  70. Ferreira, R., Antunes, L., Finlay, B. B. and Rall, G. F. (2010). Should the human microbiome be considered when developing vaccines. PLoS Pathog 6(11): e1001190.
  71. Ferreira, R. B., Gill, N., Willing, B. P., Antunes, L. C., Russell, S. L., Croxen, M. A. and Finlay, B. B. (2011). The intestinal microbiota plays a role in Salmonella-induced colitis independent of pathogen colonization. PLoS One 6(5): e20338.