联合作者(
Samantha J. Griffiths Division of Pathway and Infection Medicine, University of Edinburgh, UK
2 protocols

Jürgen Haas
  • Division of Pathway and Infection Medicine, University of Edinburgh, UK
研究方向
  • 系统生物学
  • 已发表 protocol 2

Education

Ph.D. in Immunology and Molecular Biology, the Technical University and the Ludwig-Maximilians University, Munich, 1994

Current position

Head of Clinical Research, University of Edinburgh, since 2013
Honorary consultant at the Specialist Virology Centre at the Royal Infirmary Edinburgh

Publications (selected list)

  1. Griffiths, S. J., Koegl, M., Boutell, C., Zenner, H. L., Crump, C. M., Pica, F., Gonzalez, O., Friedel, C. C., Barry, G., Martin, K., Craigon, M. H., Chen, R., Kaza, L. N., Fossum, E., Fazakerley, J. K., Efstathiou, S., Volpi, A., Zimmer, R., Ghazal, P. and Haas, J. (2013). A systematic analysis of host factors reveals a Med23-interferon-lambda regulatory axis against herpes simplex virus type 1 replication. PLoS Pathog 9(8): e1003514.
  2. Tahoun, A., Mahajan, S., Paxton, E., Malterer, G., Donaldson, D. S., Wang, D., Tan, A., Gillespie, T. L., O'Shea, M., Roe, A. J., Shaw, D. J., Gally, D. L., Lengeling, A., Mabbott, N. A., Haas, J. and Mahajan, A. (2012). Salmonella transforms follicle-associated epithelial cells into M cells to promote intestinal invasion. Cell Host Microbe 12(5): 645-656.
  3. Jing, L., Haas, J., Chong, T. M., Bruckner, J. J., Dann, G. C., Dong, L., Marshak, J. O., McClurkan, C. L., Yamamoto, T. N., Bailer, S. M., Laing, K. J., Wald, A., Verjans, G. M. and Koelle, D. M. (2012). Cross-presentation and genome-wide screening reveal candidate T cells antigens for a herpes simplex virus type 1 vaccine. J Clin Invest 122(2): 654-673.
  4. Dolken, L., Malterer, G., Erhard, F., Kothe, S., Friedel, C. C., Suffert, G., Marcinowski, L., Motsch, N., Barth, S., Beitzinger, M., Lieber, D., Bailer, S. M., Hoffmann, R., Ruzsics, Z., Kremmer, E., Pfeffer, S., Zimmer, R., Koszinowski, U. H., Grasser, F., Meister, G. and Haas, J. (2010). Systematic analysis of viral and cellular microRNA targets in cells latently infected with human gamma-herpesviruses by RISC immunoprecipitation assay. Cell Host Microbe 7(4): 324-334.
  5. Fossum, E., Friedel, C. C., Rajagopala, S. V., Titz, B., Baiker, A., Schmidt, T., Kraus, T., Stellberger, T., Rutenberg, C., Suthram, S., Bandyopadhyay, S., Rose, D., von Brunn, A., Uhlmann, M., Zeretzke, C., Dong, Y. A., Boulet, H., Koegl, M., Bailer, S. M., Koszinowski, U., Ideker, T., Uetz, P., Zimmer, R. and Haas, J. (2009). Evolutionarily conserved herpesviral protein interaction networks. PLoS Pathog 5(9): e1000570.   
  6. Uetz, P., Dong, Y. A., Zeretzke, C., Atzler, C., Baiker, A., Berger, B., Rajagopala, S. V., Roupelieva, M., Rose, D., Fossum, E. and Haas, J. (2006). Herpesviral protein networks and their interaction with the human proteome. Science 311(5758): 239-242.
  7. Muranyi, W., Haas, J., Wagner, M., Krohne, G. and Koszinowski, U. H. (2002). Cytomegalovirus recruitment of cellular kinases to dissolve the nuclear lamina. Science 297(5582): 854-857.
  8. Kliche, S., Nagel, W., Kremmer, E., Atzler, C., Ege, A., Knorr, T., Koszinowski, U., Kolanus, W. and Haas, J. (2001). Signaling by human herpesvirus 8 kaposin A through direct membrane recruitment of cytohesin-1. Mol Cell 7(4): 833-843.
  9. Haas, J., Park, E. C. and Seed, B. (1996). Codon usage limitation in the expression of HIV-1 envelope glycoprotein. Curr Biol 6(3): 315-324.
  10. Haas, J. G., Baeuerle, P. A., Riethmuller, G. and Ziegler-Heitbrock, H. W. (1990). Molecular mechanisms in down-regulation of tumor necrosis factor expression. Proc Natl Acad Sci U S A 87(24): 9563-9567.
已发表 protocol 2篇
VZV Replication Assays
水痘带状疱疹复制分析

作者:Samantha J. Griffiths and Jürgen Haas日期:08/20/2014,浏览量:8261,Q&A: 0
Varicella zoster virus (VZV) is a human herpesvirus which causes Varicella (chickenpox) upon primary infection and Zoster (shingles) following reactivation from latency (von Bokay, 1909). Whilst VZV is extensively studied, inherent features of VZV ...
siRNA Screening for Genes Involved in HSV-1 Replication
对参与HSV-1病毒复制的基因进行siRNA筛选

作者:Samantha J. Griffiths and Jürgen Haas日期:08/20/2014,浏览量:7864,Q&A: 0
Small interfering RNAs (siRNAs) are small (typically 18-24 nucleotides) RNA molecules capable of silencing gene expression post-transcriptionally and as such, they provide a simple method by which the role of individual genes in complex cellular ...