Education

Ph.D., Department of Molecular Biology, Memorial Sloan-Kettering Cancer Center Division, Cornell University, NY, USA, 1995

Current position

Chief Scientific Advisor, Apta SSD Co. Ltd, Seoul, Korea (04/2013-present)
CSO, BexCore Inc., Seoul, Korea (08/2009-present)
Professor, Department of Molecular Biology, Institute of Nanosensor and Biotechnology,
Dankook University (03/1997-present)

Publications (since 2008)

Research articles

1. Han, S. R. and Lee, S. W. (2013). In vitro selection of RNA aptamer specific to Salmonella typhimurium. J Microbiol Biotechnol 23(6): 878-884.
   
2. Han, S. R. and Lee, S. W. (2013). In vitro selection of RNA aptamer specific to Salmonella typhimurium. J Microbiol Biotechnol 23(6): 878-884.
   
3. Lee, C. H., Lee, Y. J., Kim, J. H., Lim, J. H., Han, W., Lee, S. H., Noh, G. J. and Lee, S. W. (2013). Inhibition of hepatitis C virus (HCV) replication by specific RNA aptamers against HCV NS5B RNA replicase. J Virol 87(12): 7064-7074. (Selected as ‘Press Release’ by American Society for Microbiology, http://www.asm.org/index.php/asm-newsroom2/88-news-room/journal-tipsheets/91691-new-agent-inhibits-hcv-replication-in-mouse-models-no-resistance-seen) (Selected in 'Highlights' section in the journal 'Microbe 2013, Vol. 8, No. 6, Page 241')
   
4. Hong, H. W., Lee, S. W. and Myung, H. (2013). Induced degradation of Tat by nucleocapsid (NC) via the proteasome pathway and its effect on HIV transcription. Viruses 5(4): 1143-1152.
   
5. Kwon, T., Park, J., Lee, G., Nam, K., Huh, Y.-M., Lee, S.-W., Yang, J., Lee, C. Y. and Eom, K. (2013). Carbon Nanotube-Patterned Surface-Based Recognition of Carcinoembryonic Antigens in Tumor Cells for Cancer Diagnosis. The Journal of Physical Chemistry Letters 4(7): 1126-1130.
   
6. Maeng, J. S., Kim, N., Kim, C. T., Han, S. R., Lee, Y. J., Lee, S. W., Lee, M. H. and Cho, Y. J. (2012). Rapid detection of food pathogens using RNA aptamers-immobilized slide. J Nanosci Nanotechnol 12(7): 5138-5142.
   
7. Lee, Y. J., Han, S. R., Kim, N. Y., Lee, S. H., Jeong, J. S. and Lee, S. W. (2012). An RNA aptamer that binds carcinoembryonic antigen inhibits hepatic metastasis of colon cancer cells in mice. Gastroenterology 143(1): 155-165 e158. (Selected and invited as Video Abstract, http://www.youtube.com/watch?v=UfnYhhW7Yb4&list=PL1DE0E0B4378B4525&index=3&feature=plpp_video)
   
8. Won, Y. S. and Lee, S. W. (2012). Selective regression of cancer cells expressing a splicing variant of AIMP2 through targeted RNA replacement by trans-splicing ribozyme. J Biotechnol 158(1-2): 44-49.
   
9. Won, Y. S. and Lee, S. W. (2012). Cancer-specific induction of adenoviral E1A expression by group I intron-based trans-splicing ribozyme. J Microbiol Biotechnol 22(3): 431-435.
   
10. Lee, C. H., Kim, J. H., Kim, H. W., Myung, H. and Lee, S. W. (2012). Hepatitis C virus replication-specific inhibition of microRNA activity with self-cleavable allosteric ribozyme. Nucleic Acid Ther 22(1): 17-29.
    
11. Lee, Y. J. and Lee, S. W. (2012). Regression of hepatocarcinoma cells using RNA aptamer specific to alpha-fetoprotein. Biochem Biophys Res Commun 417(1): 521-527.
    
12. Lee, Y. J., Han, S. R., Maeng, J. S., Cho, Y. J. and Lee, S. W. (2012). In vitro selection of Escherichia coli O157:H7-specific RNA aptamer. Biochem Biophys Res Commun 417(1): 414-420.
    
13. Ban, G., Jeong, J.-S., and Lee, S.-W. (2011) In vivo target specificity of hCKAP2-replacing trans-splicing ribozyme. Journal of Nano & Bio Tech 8: 10-13.
    
14. Lee, C. H., and Lee, S.-W. (2011) Inhibition of hepatitis C virus (HCV) replication by hammerhead ribozyme which activity can be allosterically regulated by HCV NS5B RNA replicase. The Korean Journal of Microbiology 47: 188-193.
    
15. Ban, G., Jeong, J. S., Kim, A., Kim, S. J., Han, S. Y., Kim, I. H. and Lee, S. W. (2011). Selective and efficient retardation of cancers expressing cytoskeleton-associated protein 2 by targeted RNA replacement. Int J Cancer 129(4): 1018-1029. (Selected as a featured article in spotlight)
    
16. Kwon, B. S., Jeong, J. S., Won, Y. S., Lee, C. H., Yoon, K. S., Hyung Jung, M., Kim, I. H. and Lee, S. W. (2011). Intracellular efficacy of tumor-targeting group I intron-based trans-splicing ribozyme. J Gene Med 13(2): 89-100.
    
17. Hong, H. W., Lee, S. W. and Myung, H. (2010). Selection of peptides binding to HCV e2 and inhibiting viral infectivity. J Microbiol Biotechnol 20(12): 1769-1771.
    
18. Ban, G., Kim, A., Kim, S., and Lee, S.-W. (2010) Accurate trans-splicing reaction in vivo by hCKAP2-targeting group I intron ribozyme. Journal of Nano & Bio Tech 7: 6-9.
    
19. Chang, B., Lee, C. H., Lee, J. H. and Lee, S. W. (2010). Comparative analysis of intracellular inhibition of hepatitis C virus replication by small interfering RNAs. Biotechnol Lett 32(9): 1231-1237.
    
20. Jeong, S., Han, S. R., Lee, Y. J., Kim, J. H. and Lee, S. W. (2010). Identification of RNA aptamer specific to mutant KRAS protein. Oligonucleotides 20(3): 155-161.
    
21. Jeong, S., Han, S. R., Lee, Y. J. and Lee, S. W. (2010). Selection of RNA aptamers specific to active prostate-specific antigen. Biotechnol Lett 32(3): 379-385.
    
22. Song, M. S. and Lee, S. W. (2009). RNA Mapping of Mutant Myotonic Dystrophy Protein Kinase 3'-Untranslated Region Transcripts. Genomics & Informatics 7(4): 181-186. (Selected as cover featured article)
    
23. Kim, J.H., Ban, G., Won, Y.S., Kim, S.J., Won, R., and Lee, S.-W. (2009). Trans-splicing reaction in cells by mTERT-targeting group I intron. Journal of Nano & Bio Tech 6: 15-18.
    
24. Cho, J. S. and Lee, S. W. (2009). Sequence and structural features of RNA aptamer against myasthenic autoantibodies. Oligonucleotides 19(3): 273-280.
    
25. Ban, G., Song, M. S. and Lee, S. W. (2009). Cancer cell targeting with mouse TERT-specific group I intron of Tetrahymena thermophila. J Microbiol Biotechnol 19(9): 1070-1076.
    
26. Ahn, D. G., Jeon, I. J., Kim, J. D., Song, M. S., Han, S. R., Lee, S. W., Jung, H. and Oh, J. W. (2009). RNA aptamer-based sensitive detection of SARS coronavirus nucleocapsid protein. Analyst 134(9): 1896-1901.
    
27. Song, M. S., Jeong, J. S., Ban, G., Lee, J. H., Won, Y. S., Cho, K. S., Kim, I. H. and Lee, S. W. (2009). Validation of tissue-specific promoter-driven tumor-targeting trans-splicing ribozyme system as a multifunctional cancer gene therapy device in vivo. Cancer Gene Ther 16(2): 113-125. (Selected as a featured article)
    
28. Hwang, B., Lim, J. H., Hahm, B., Jang, S. K. and Lee, S. W. (2009). hnRNP L is required for the translation mediated by HCV IRES. Biochem Biophys Res Commun 378(3): 584-588.
    
29. Song, M.S., Jeong, J.-S., and Lee, S.-W. (2008) Inhibition of telomerase expression in vivo by hTERT targeting trans-splicing ribozyme. Journal of Nano & Bio Tech 5: 14-17.
    
30. Kim, J., Jang, S., Lee, C. and Lee, S. (2008). Development of Trans-Splicing Aptazyme Which Can Specifically Modify Hepatitis C Virus Genome. The Korean Journal of Microbiology 44.
    
31. Song, M. S. and Lee, S. W. (2008). In Vivo Target RNA Specificity of Trans-Splicing Phenomena by the Group I Intron. Genomics & Informatics 6(2): 84-86.
    
32. Jeong, J. S., Lee, S. W., Hong, S. H., Lee, Y. J., Jung, H. I., Cho, K. S., Seo, H. H., Lee, S. J., Park, S., Song, M. S., Kim, C. M. and Kim, I. H. (2008). Antitumor effects of systemically delivered adenovirus harboring trans-splicing ribozyme in intrahepatic colon cancer mouse model. Clin Cancer Res 14(1): 281-290.
    
33. Hong, S. H., Jeong, J. S., Lee, Y. J., Jung, H. I., Cho, K. S., Kim, C. M., Kwon, B. S., Sullenger, B. A., Lee, S. W.* and Kim, I. H.* (2008). In vivo reprogramming of hTERT by trans-splicing ribozyme to target tumor cells. Mol Ther 16(1): 74-80.
    

Reviews and chapters

1. Lee, S. W. and Jeong, J. S. (2014). Use of tumor-targeting trans-splicing ribozyme for cancer treatment. Methods Mol Biol 1103: 83-95.
   
2. Lee, C. H., and Lee, S.-W. (2013) Colony forming assay for HCV-replicon cell line. Bio-Protocol In press.
   
3. Lee, S.-W. (2013) 'Trend analysis of gene therapy development' in Drug Research Trends. Bioin Special Webzine. No. 35.
   
4. Lee, S. W. (2011). Introducing the Korean Oligonucleotide Therapeutics Society. Nucleic Acid Ther 21(3): 123.
   
5. Lee, S. J., Lee, S. W., Jeong, J. S. and Kim, I. H. (2010). In vivo reprogramming of human telomerase reverse transcriptase (hTERT) by trans-splicing ribozyme to target tumor cells. Methods Mol Biol 629: 307-321.