Education
Ph.D. in Medical Science, Osaka University, 1979
Current Position
Professor in Department of Virology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
Publications (since 2010)
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Yamashita, A., Kawashita, N., Li, YG, Sasaki, T., Tao, R., Yang, P., Ramasoota, P., and Ikuta, K.: Human neutralizing epitope in the envelope domain II of dengue virus recognizing by dengue patients shows dynamic conformational change after fusion process. Future Virology, in press.
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Yasugi, M., Kubota-Koketsu, R., Yamashita, A., Kawashita, N., Du, A., Misaki, R., Kuhara, M., Boonsathorn, N., Fujiyama, K., Okuno, Y., Nakaya, T. and Ikuta, K. (2013). Emerging antigenic variants at the antigenic site Sb in pandemic A(H1N1)2009 influenza virus in Japan detected by a human monoclonal antibody. PLoS One 8(10): e77892.
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Wangroongsarb, P., Kohda, T., Jittaprasartsin, C., Suthivarakom, K., Kamthalang, T., Umeda, K., Sawanpanyalert, P., Kozaki, S., and Ikuta, K.: Molecular characterization of Clostridium botulinum isolates from Foodborne Outbreaks in Thailand, 2010. PLoS One, in press.
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Sasaki, T., Setthapramote, C., Kurosu, T., Nishimura, M., Asai, A., Omokoko, M. D., Pipattanaboon, C., Pitaksajjakul, P., Limkittikul, K., Subchareon, A., Chaichana, P., Okabayashi, T., Hirai, I., Leaungwutiwong, P., Misaki, R., Fujiyama, K., Ono, K., Okuno, Y., Ramasoota, P. and Ikuta, K. (2013). Dengue virus neutralization and antibody-dependent enhancement activities of human monoclonal antibodies derived from dengue patients at acute phase of secondary infection. Antiviral Res 98(3): 423-431.
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Watanabe, Y., Ibrahim, M. S. and Ikuta, K. (2013). Evolution and control of H5N1. A better understanding of the evolution and diversity of H5N1 flu virus and its host species in endemic areas could inform more efficient vaccination and control strategies. EMBO Rep 14(2): 117-122.
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Inoue, Y., Kubota-Koketsu, R., Yamashita, A., Nishimura, M., Ideno, S., Ono, K., Okuno, Y. and Ikuta, K. (2013). Induction of anti-influenza immunity by modified green fluorescent protein (GFP) carrying hemagglutinin-derived epitope structure. J Biol Chem 288(7): 4981-4990.
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Yasugi, M., Kubota-Koketsu, R., Yamashita, A., Kawashita, N., Du, A., Sasaki, T., Nishimura, M., Misaki, R., Kuhara, M., Boonsathorn, N., Fujiyama, K., Okuno, Y., Nakaya, T. and Ikuta, K. (2013). Human monoclonal antibodies broadly neutralizing against influenza B virus. PLoS Pathog 9(2): e1003150.
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Sasaki, T., Kubota-Koketsu, R., Takei, M., Hagihara, T., Iwamoto, S., Murao, T., Sawami, K., Fukae, D., Nakamura, M., Nagata, E., Kawakami, A., Mitsubayashi, Y., Ohno, M., Uehara, Y., Fukukawa, T., Kanai, Y., Kosaka, M. and Ikuta, K. (2012). Reliability of a newly-developed immunochromatography diagnostic kit for pandemic influenza A/H1N1pdm virus: implications for drug administration. PLoS One 7(11): e50670.
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Watanabe, Y., Ibrahim, M. S., Suzuki, Y. and Ikuta, K. (2012). The changing nature of avian influenza A virus (H5N1). Trends Microbiol 20(1): 11-20.
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Watanabe, Y., Ibrahim, M. S., Ellakany, H. F., Kawashita, N., Daidoji, T., Takagi, T., Yasunaga, T., Nakaya, T. and Ikuta, K. (2012). Antigenic analysis of highly pathogenic avian influenza virus H5N1 sublineages co-circulating in Egypt. J Gen Virol 93(Pt 10): 2215-2226.
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Matsumoto, Y., Hayashi, Y., Omori, H., Honda, T., Daito, T., Horie, M., Ikuta, K., Fujino, K., Nakamura, S., Schneider, U., Chase, G., Yoshimori, T., Schwemmle, M. and Tomonaga, K. (2012). Bornavirus closely associates and segregates with host chromosomes to ensure persistent intranuclear infection. Cell Host Microbe 11(5): 492-503.
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Yasugi, M., Nakamura, S., Daidoji, T., Kawashita, N., Ramadhany, R., Yang, C. S., Yasunaga, T., Iida, T., Horii, T., Ikuta, K., Takahashi, K. and Nakaya, T. (2012). Frequency of D222G and Q223R hemagglutinin mutants of pandemic (H1N1) 2009 influenza virus in Japan between 2009 and 2010. PLoS One 7(2): e30946.
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Boonchawalit, S., Jullaksorn, D., Uttiyoung, J., Yowang, A., Krathong, N., Chautrakul, S., Yamashita, A., Ikuta, K., Roobsoong, A., Kanitvittaya, S., Sawanpanyalert, P. and Kameoka, M. (2011). Molecular evolution of HIV-1 CRF01_AE Env in Thai patients. PLoS One 6(11): e27098.
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Watanabe, Y., Ibrahim, M. S., Ellakany, H. F., Abd El-Hamid, H. S. and Ikuta, K. (2011). Genetic diversification of H5N1 highly pathogenic avian influenza A virus during replication in wild ducks. J Gen Virol 92(Pt 9): 2105-2110.
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Watanabe, Y., Ibrahim, M. S., Ellakany, H. F., Kawashita, N., Mizuike, R., Hiramatsu, H., Sriwilaijaroen, N., Takagi, T., Suzuki, Y. and Ikuta, K. (2011). Acquisition of human-type receptor binding specificity by new H5N1 influenza virus sublineages during their emergence in birds in Egypt. PLoS Pathog 7(5): e1002068.
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Mizuike, R., Sasaki, T., Baba, K., Iwamoto, H., Shibai, Y., Kosaka, M., Kubota-Koketsu, R., Yang, C. S., Du, A., Sakudo, A., Tsujikawa, M., Yunoki, M. and Ikuta, K. (2011). Development of two types of rapid diagnostic test kits to detect the hemagglutinin or nucleoprotein of the swine-origin pandemic influenza A virus H1N1. Clin Vaccine Immunol 18(3): 494-499.
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Kayamuro, H., Yoshioka, Y., Abe, Y., Arita, S., Katayama, K., Nomura, T., Yoshikawa, T., Kubota-Koketsu, R., Ikuta, K., Okamoto, S., Mori, Y., Kunisawa, J., Kiyono, H., Itoh, N., Nagano, K., Kamada, H., Tsutsumi, Y. and Tsunoda, S. (2010). Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J Virol 84(24): 12703-12712.
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Soonthornsata, B., Tian, Y. S., Utachee, P., Sapsutthipas, S., Isarangkura-na-Ayuthaya, P., Auwanit, W., Takagi, T., Ikuta, K., Sawanpanyalert, P., Kawashita, N. and Kameoka, M. (2010). Design and evaluation of antiretroviral peptides corresponding to the C-terminal heptad repeat region (C-HR) of human immunodeficiency virus type 1 envelope glycoprotein gp41. Virology 405(1): 157-164.
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Kameoka, M., Isarangkura-na-Ayuthaya, P., Kameoka, Y., Sapsutthipas, S., Soonthornsata, B., Nakamura, S., Tokunaga, K., Sawanpanyalert, P., Ikuta, K. and Auwanit, W. (2010). The role of lysine residue at amino acid position 165 of human immunodeficiency virus type 1 CRF01_AE Gag in reducing viral drug susceptibility to protease inhibitors. Virology 405(1): 129-138.
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Arias, J. F., Nishihara, R., Bala, M. and Ikuta, K. (2010). High systemic levels of interleukin-10, interleukin-22 and C-reactive protein in Indian patients are associated with low in vitro replication of HIV-1 subtype C viruses. Retrovirology 7: 15.
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Utachee, P., Nakamura, S., Isarangkura-Na-Ayuthaya, P., Tokunaga, K., Sawanpanyalert, P., Ikuta, K., Auwanit, W. and Kameoka, M. (2010). Two N-linked glycosylation sites in the V2 and C2 regions of human immunodeficiency virus type 1 CRF01_AE envelope glycoprotein gp120 regulate viral neutralization susceptibility to the human monoclonal antibody specific for the CD4 binding domain. J Virol 84(9): 4311-4320.
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Horie, M., Honda, T., Suzuki, Y., Kobayashi, Y., Daito, T., Oshida, T., Ikuta, K., Jern, P., Gojobori, T., Coffin, J. M. and Tomonaga, K. (2010). Endogenous non-retroviral RNA virus elements in mammalian genomes. Nature 463(7277): 84-87.
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Ueda, M., Daidoji, T., Du, A., Yang, C. S., Ibrahim, M. S., Ikuta, K. and Nakaya, T. (2010). Highly pathogenic H5N1 avian influenza virus induces extracellular Ca2+ influx, leading to apoptosis in avian cells. J Virol 84(6): 3068-3078.
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Yunoki, M., Kubota-Koketsu, R., Urayama, T., Sasaki, T., Analiwa, D.,
Konoshima, Y., Ideno, S., Fukunaga, Y., Morikawa, S., Hiroi, S.,
Takahashi, K., Okuno, Y., Hagiwara, K. and Ikuta, K. (2010). Significant neutralizing activity of human immunoglobulin preparations against pandemic 2009 H1N1. Br J Haematol 148(6): 953-955.
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Honda, T., Horie, M., Daito, T., Ikuta, K. and Tomonaga, K. (2009). Molecular chaperone BiP interacts with Borna disease virus glycoprotein at the cell surface. J Virol 83(23): 12622-12625.