Education

Ph.D. in Physiology, University of Tennessee, Memphis, TN, 1991

Current position

Tenure Professor, Oral Biology and Institute of Behavior Medicine, Ohio State University (2009-present)
Chair, Oral Biology Graduate Program, Ohio State University (2009-present)

Publications

1. Chen, Q., Tarr, A. J., Liu, X., Wang, Y., Reed, N. S., Demarsh, C. P., Sheridan, J. F. and Quan, N. (2013). Controlled progressive innate immune stimulation regimen prevents the induction of sickness behavior in the open field test. J Inflamm Res 6: 91-98.
   
2. Qian, J., Zhu, L., Li, Q., Belevych, N., Chen, Q., Zhao, F., Herness, S. and Quan, N. (2012). Interleukin-1R3 mediates interleukin-1-induced potassium current increase through fast activation of Akt kinase. Proc Natl Acad Sci U S A 109(30): 12189-12194.
   
3. Tarr, A. J., Chen, Q., Wang, Y., Sheridan, J. F. and Quan, N. (2012). Neural and behavioral responses to low-grade inflammation. Behav Brain Res 235(2): 334-341.
   
4. An, Y., Chen, Q. and Quan, N. (2011). Interleukin-1 exerts distinct actions on different cell types of the brain in vitro. J Inflamm Res 2011(4): 11-20.
   
5. Li, Q., Powell, N., Zhang, H., Belevych, N., Ching, S., Chen, Q., Sheridan, J., Whitacre, C. and Quan, N. (2011). Endothelial IL-1R1 is a critical mediator of EAE pathogenesis. Brain Behav Immun 25(1): 160-167.
   
6. Belevych, N., Buchanan, K., Chen, Q., Bailey, M. and Quan, N. (2010). Location-specific activation of the paraventricular nucleus of the hypothalamus by localized inflammation. Brain Behav Immun 24(7): 1137-1147.
   
7. Li, Q., Zhang, H., Chen, Q. and Quan, N. (2010). Existence of seven human IL-1R1 promoters. J Inflamm Res 2010(3): 17-24.
   
8. Reiser, P. J., Bicer, S., Chen, Q., Zhu, L. and Quan, N. (2009). Masticatory (;superfast') myosin heavy chain and embryonic/atrial myosin light chain 1 in rodent jaw-closing muscles. J Exp Biol 212(Pt 16): 2511-2519.
   
9. Chen, Q., Zhang, H., Li, Q., An, Y., Herkenham, M., Lai, W., Popovich, P., Agarwal, S. and Quan, N. (2009). Three Promoters Regulate Tissue- and Cell Type-specific Expression of Murine Interleukin-1 Receptor Type I. J Biol Chem 284(13): 8703-8713.
   
10. Bicer, S., Reiser, P. J., Ching, S. and Quan, N. (2009). Induction of muscle weakness by local inflammation: an experimental animal model. Inflamm Res 58(4): 175-183.
    
11. Zhang, H., Ching, S., Chen, Q., Li, Q., An, Y. and Quan, N. (2008). Localized inflammation in peripheral tissue signals the CNS for sickness response in the absence of interleukin-1 and cyclooxygenase-2 in the blood and brain. Neuroscience 157(4): 895-907.
    
12. Engler, H., Bailey, M. T., Engler, A., Stiner-Jones, L. M., Quan, N. and Sheridan, J. F. (2008). Interleukin-1 receptor type 1-deficient mice fail to develop social stress-associated glucocorticoid resistance in the spleen. Psychoneuroendocrinology 33(1): 108-117.
    
13. Ching, S., Zhang, H., Belevych, N., He, L., Lai, W., Pu, X. A., Jaeger, L. B., Chen, Q. and Quan, N. (2007). Endothelial-specific knockdown of interleukin-1 (IL-1) type 1 receptor differentially alters CNS responses to IL-1 depending on its route of administration. J Neurosci 27(39): 10476-10486.
    
14. Ching, S., Zhang, H., Chen, Q. and Quan, N. (2007). Differential expression of extracellular matrix and adhesion molecule genes in the brain of juvenile versus adult mice in responses to intracerebroventricular administration of IL-1. Neuroimmunomodulation 14(1): 46-56.
    
15. Dossumbekova, A., Anghelina, M., Madhavan, S., He, L., Quan, N., Knobloch, T. and Agarwal, S. (2007). Inhibition of IKK activity mediates attenuation of proinflammatory gene induction by Biomechanical signals in chondrocytes. Arthritis and Rheumatism 56: 3284-96.
    
16. Ching, S., Zhang, H., Lai, W. and Quan, N. (2006). Peripheral injection of lipopolysaccharide prevents brain recruitment of leukocytes induced by central injection of interleukin-1. Neuroscience 137(2): 717-726.
    
17. Chen, R., Tilley, M. R., Wei, H., Zhou, F., Zhou, F. M., Ching, S., Quan, N., Stephens, R. L., Hill, E. R., Nottoli, T., Han, D. D. and Gu, H. H. (2006). Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter. Proc Natl Acad Sci U S A 103(24): 9333-9338.
    
18. Dunn, A. J., Swiergiel, A. H., Zhang, H. and Quan, N. (2006). Reduced ingestion of sweetened milk induced by interleukin-1 and lipopolysaccharide is associated with induction of cyclooxygenase-2 in brain endothelia. Neuroimmunomodulation 13(2): 96-104.
    
19. Quan, N. (2006). Brain's firewall: blood-brain barrier actively regulates neuroimmune information flow. Brain Behav Immun 20(5): 447-448.
    
20. Ching, S., He, L., Lai, W. and Quan, N. (2005). IL-1 type I receptor plays a key role in mediating the recruitment of leukocytes into the central nervous system. Brain Behav Immun 19(2): 127-137.
    
21. Horan, M. P., Quan, N., Subramanian, S. V., Strauch, A. R., Gajendrareddy, P. K. and Marucha, P. T. (2005). Impaired wound contraction and delayed myofibroblast differentiation in restraint-stressed mice. Brain Behav Immun 19(3): 207-216.
    
22. Pyter, L. M., Samuelsson, A. R., Quan, N. and Nelson, R. J. (2005). Photoperiod alters hypothalamic cytokine gene expression and sickness responses following immune challenge in female Siberian hamsters (Phodopus sungorus). Neuroscience 131(4): 779-784.
    
23. Ledeboer, A., Gamanos, M., Lai, W., Maier, S. F., Watkins, L. R. and Quan, N. (2005). Role of spinal cord nuclear factor B (NF-B) activation in rat models of pain facilitation. Eur J Neurosci 22 8: 1977-1986.