Education
Ph.D. in Virology, Department of Immunology and Virology, Rush University, 2003
Current position
Senior Medical Writer, Global Medical Publishing, AbbVie Inc., North Chicago, IL, USA
Publications
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Barretto, N., Sainz, B., Jr., Hussain, S. and Uprichard, S. L. (2014). Determining the involvement and therapeutic implications of host cellular factors in hepatitis C virus cell-to-cell spread. J Virol 88(9): 5050-5061.
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Hussain, S., Barretto, N. and Uprichard, S. L. (2012). New hepatitis C virus drug discovery strategies and model systems. Expert Opin Drug Discov 7(9): 849-859.
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Sainz, B., Jr., Barretto, N., Martin, D. N., Hiraga, N., Imamura, M., Hussain, S., Marsh, K. A., Yu, X., Chayama, K., Alrefai, W. A. and Uprichard, S. L. (2012). Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor. Nat Med 18(2): 281-285.
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Sainz, B., Jr., Barretto, N., Yu, X., Corcoran, P. and Uprichard, S. L. (2012). Permissiveness of human hepatoma cell lines for HCV infection. Virol J 9: 30.
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Sainz, B., Jr., Barretto, N. and Uprichard, S. L. (2009). Hepatitis C virus infection in phenotypically distinct Huh7 cell lines. PLoS One 4(8): e6561.
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Devaraj, S. G., Wang, N., Chen, Z., Chen, Z., Tseng, M., Barretto, N., Lin, R., Peters, C. J., Tseng, C. T., Baker, S. C. and Li, K. (2007). Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus. J Biol Chem 282(44): 32208-32221.
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Ratia, K., Saikatendu, K. S., Santarsiero, B. D., Barretto, N., Baker, S. C., Stevens, R. C. and Mesecar, A. D. (2006). Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme. Proc Natl Acad Sci U S A 103(15): 5717-5722.
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Barretto, N., Jukneliene, D., Ratia, K., Chen, Z., Mesecar, A. D. and Baker, S. C. (2005). The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity. J Virol 79(24): 15189-15198. (Selected for JVI spotlight)
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Barretto, N., Hallak, L. K. and Peeples, M. E. (2003). Neuraminidase treatment of respiratory syncytial virus-infected cells or virions, but not target cells, enhances cell-cell fusion and infection. Virology 313(1): 33-43.
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Techaarpornkul, S., Barretto, N. and Peeples, M. E. (2001). Functional analysis of recombinant respiratory syncytial virus deletion mutants lacking the small hydrophobic and/or attachment glycoprotein gene. J Virol 75(15): 6825-6834.
Book chapters
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Barretto, N., Jukneliene, D., Ratia, K., Chen, Z., Mesecar, A. D. and Baker, S. C. (2006). Deubiquitinating activity of the SARS-CoV papain-like protease. Adv Exp Med Biol 581: 37-41.