Education

Ph.D. in Biochemistry, Hebrew University of Jerusalem, Jerusalem, Israel, 1995

Current position

Associate Professor, Department of Biological Regulation, Weizmann Institute of Science (2007-present)

Publications (since 2005)

Original contributions

1. Weaver, D., Eisner, V., Liu, X., Varnai, P., Hunyady, L., Gross, A. and Hajnoczky, G. (2014). Distribution and Apoptotic Function of Outer Membrane Proteins Depend on Mitochondrial Fusion. Mol Cell. (Epub ahead of print)
   
2. Shamas-Din, A., Bindner, S., Zhu, W., Zaltsman, Y., Campbell, C., Gross, A., Leber, B., Andrews, D. W. and Fradin, C. (2013). tBid undergoes multiple conformational changes at the membrane required for Bax activation. J Biol Chem 288(30): 22111-22127.
   
3. Cabon, L., Galan-Malo, P., Bouharrour, A., Delavallee, L., Brunelle-Navas, M. N., Lorenzo, H. K., Gross, A. and Susin, S. A. (2012). BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation. Cell Death Differ 19(2): 245-256.
   
4. Katz, C., Zaltsman-Amir, Y., Mostizky, Y., Kollet, N., Gross, A. and Friedler, A. (2012). Molecular basis of the interaction between proapoptotic truncated BID (tBID) protein and mitochondrial carrier homologue 2 (MTCH2) protein: key players in mitochondrial death pathway. J Biol Chem 287(18): 15016-15023.
   
5. Maryanovich, M., Oberkovitz, G., Niv, H., Vorobiyov, L., Zaltsman, Y., Brenner, O., Lapidot, T., Jung, S. and Gross, A. (2012). The ATM-BID pathway regulates quiescence and survival of haematopoietic stem cells. Nat Cell Biol 14(5): 535-541.
   
6. Yivgi-Ohana, N., Eifer, M., Addadi, Y., Neeman, M. and Gross, A. (2011). Utilizing mitochondrial events as biomarkers for imaging apoptosis. Cell Death Dis 2: e166.
   
7. Zaltsman, Y., Shachnai, L., Yivgi-Ohana, N., Schwarz, M., Maryanovich, M., Houtkooper, R. H., Vaz, F. M., De Leonardis, F., Fiermonte, G., Palmieri, F., Gillissen, B., Daniel, P. T., Jimenez, E., Walsh, S., Koehler, C. M., Roy, S. S., Walter, L., Hajnoczky, G. and Gross, A. (2010). MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria. Nat Cell Biol 12(6): 553-562.
8. Ziporen, L., Donin, N., Shmushkovich, T., Gross, A. and Fishelson, Z. (2009). Programmed necrotic cell death induced by complement involves a Bid-dependent pathway. J Immunol 182(1): 515-521.
   
9. Schungel, S., Buitrago-Molina, L. E., Nalapareddy, P., Lebofsky, M., Manns, M. P., Jaeschke, H., Gross, A. and Vogel, A. (2009). The strength of the Fas ligand signal determines whether hepatocytes act as type 1 or type 2 cells in murine livers. Hepatology 50(5): 1558-1566.
   
10. Yacobi, K., Tsafriri, A. and Gross, A. (2007). Luteinizing hormone-induced caspase activation in rat preovulatory follicles is coupled to mitochondrial steroidogenesis. Endocrinology 148(4): 1717-1726.
    
11. Konig, H. G., Rehm, M., Gudorf, D., Krajewski, S., Gross, A., Ward, M. W. and Prehn, J. H. (2007). Full length Bid is sufficient to induce apoptosis of cultured rat hippocampal neurons. BMC Cell Biol 8: 7.
    
12. Oberkovitz, G., Regev, L. and Gross, A. (2007). Nucleocytoplasmic shuttling of BID is involved in regulating its activities in the DNA-damage response. Cell Death Differ 14(9): 1628-1634.
    
13. Zinkel, S. S., Hurov, K. E., Ong, C., Abtahi, F. M., Gross, A. and Korsmeyer, S. J. (2005). A role for proapoptotic BID in the DNA-damage response. Cell 122(4): 579-591.
    
14. Grinberg, M., Schwarz, M., Zaltsman, Y., Eini, T., Niv, H., Pietrokovski, S. and Gross, A. (2005). Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha. Mol Cell Biol 25(11): 4579-4590.
    
15. Kamer, I., Sarig, R., Zaltsman, Y., Niv, H., Oberkovitz, G., Regev, L., Haimovich, G., Lerenthal, Y., Marcellus, R. C. and Gross, A. (2005). Proapoptotic BID is an ATM effector in the DNA-damage response. Cell 122(4): 593-603.
    

Invited reviews/commenteries

1. Zinkel, S. S., Yin, X. M. and Gross, A. (2013). Rejuvenating Bi(d)ology. Oncogene 32(27): 3213-3219.
   
2. Maryanovich, M. and Gross, A. (2013). A ROS rheostat for cell fate regulation. Trends Cell Biol 23(3): 129-134.
   
3. Robinson, A. J., Kunji, E. R. and Gross, A. (2012). Mitochondrial carrier homolog 2 (MTCH2): the recruitment and evolution of a mitochondrial carrier protein to a critical player in apoptosis. Exp Cell Res 318(11): 1316-1323.
   
4. Gross, A. (2011). A yeast BH3-only protein for the rescue. Cell Death Differ 18(10): 1543-1544.
   
5. Gross, A. (2010). M(a)TCH-ing up mitochondrial apoptosis. Cell Cycle 9(15): 2925-2926.
   
6. Gross, A. (2010). Aven-uing between nuclear export and cell cycle arrest. Cell Cycle 9(20): 4043-4044.
   
7. Gross, A. (2008). A new Aven-ue to DNA-damage checkpoints. Trends Biochem Sci 33(11): 514-516.
   
8. Schwarz, M., Andrade-Navarro, M. A. and Gross, A. (2007). Mitochondrial carriers and pores: key regulators of the mitochondrial apoptotic program? Apoptosis 12(5): 869-876.
   
9. Zinkel, S. S., Hurov, K. E. and Gross, A. (2007). Bid plays a role in the DNA damage response. Cell 130(1): 9-10; author reply 10-11.
   
10. Gross, A. (2006). BID as a double agent in cell life and death. Cell Cycle 5(6): 582-584.
    
11. Zinkel, S., Gross, A. and Yang, E. (2006). BCL2 family in DNA damage and cell cycle control. Cell Death Differ 13(8): 1351-1359.
    
12. Gross, A. (2005). Mitochondrial carrier homolog 2: a clue to cracking the BCL-2 family riddle? J Bioenerg Biomembr 37(3): 113-119.