Neuroscience

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    Protocols in Current Issue
    A Novel Standardized Peripheral Nerve Transection Method and a Novel Digital Pressure Sensor Device Construction for Peripheral Nerve Crush Injury
    [Abstract]

    Peripheral nerve injury (PNI) is common in all walks of life, and the most common PNIs are nerve crush and nerve transection. While optimal functional recovery after crush injury occurs over weeks, functional recovery after nerve transection with microsurgical repair and grafting is poor, and associated with permanent disability. The gold-standard

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    Isolation and Electrophysiology of Murine Sympathetic Postganglionic Neurons in the Thoracic Paravertebral Ganglia
    Authors:  Mallika Halder, Michael Lee McKinnon, Yaqing Li, Peter Wenner and Shawn Hochman, date: 10/20/2021, view: 969, Q&A: 0
    [Abstract]

    The thoracic paravertebral sympathetic chain postganglionic neurons (tSPNs) represent the predominant sympathetic control of vascular function in the trunk and upper extremities. tSPNs cluster to form ganglia linked by an interganglionic nerve and receive multisegmental convergent and divergent synaptic input from cholinergic sympathetic

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    Sciatic Nerve Cut and Repair Using Fibrin Glue in Adult Mice
    Authors:  Erica T. Akhter, Travis M. Rotterman, Arthur W. English and Francisco J. Alvarez, date: 09/20/2019, view: 3253, Q&A: 0
    [Abstract] Peripheral nerve injury (PNI) is an excellent model for studying neural responses to injury and elucidating the mechanisms that can facilitate axon regeneration. As such, several animal models have been employed to study regenerative mechanisms after PNI, including Aplysia, zebrafish, rabbits, cats and rodents. This protocol describes how to ...
    Optical Stimulation and Electrophysiological Analysis of Regenerating Peripheral Axons
    Authors:  Patricia J. Ward and Arthur W. English, date: 06/20/2019, view: 3017, Q&A: 0
    [Abstract] Although axons in the peripheral nervous system can regenerate, functional recovery after nerve injuries is poor. Activity-based therapies, such as exercise and electrical stimulation, enhance the regeneration of cut peripheral axons. Despite their effectiveness, clinical application of these experimental techniques has been limited. At least part ...
    Preparation of Teased Nerve Fibers from Rat Sciatic Nerve
    Authors:  Jinkun Wen, Lixia Li, Dandan Tan and Jiasong Guo, date: 10/05/2017, view: 9909, Q&A: 0
    [Abstract] Compared to tissue sectioning techniques, the technique of teasing single nerve fibers provides a better way to understand the structures of myelin sheaths and axons of the peripheral myelinated nerves. This protocol describes a method for preparation of teased single nerve fibers from rat sciatic nerve. In this protocol, fixed nerves are teased ...



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