Separate interview guides were developed for PLHIV and health workers. Both interview guides included open-ended questions framed using the COM-B model, designed to explore potential barriers to and facilitators of acceptance and completion of 3HP treatment offered via DOT or SAT delivery strategies by PLHIV at the Mulago AIDS clinic. We defined acceptance of 3HP as the willingness by PLHIV to take the once-weekly dose of 3HP prescribed via DOT/SAT by health workers at the clinic. We defined completion of 3HP treatment as PLHIV swallowing at least 11 of 12 once-weekly doses within 16 weeks of enrollment.

The interview guides for PLHIV explored their understanding of TB (i.e., the disease itself, how it is transmitted, its prevention and treatment), their perceptions of individual risk of contracting TB disease and awareness about TPT, and their perception of its importance. Other questions were specific to 3HP and explored willingness to take 3HP if it were offered to them by their health worker, how easy/difficult it would be to remember to take the once-weekly dose, perceived advantages or disadvantages of either taking 3HP via DOT or SAT, and perceptions about the use of digital adherence technologies to support 3HP adherence and completion.

The interview guides for health workers included questions about their experiences with PLHIV at the clinic, their experiences with TB and TPT, and their perceptions about concerns that PLHIV may have about TB and TPT. The guide also explored perceived challenges or benefits that their clients may encounter with DOT vs. SAT, their own preferences for delivering 3HP by DOT vs. SAT, and their perceptions about the use of digital adherence technologies to support 3HP completion.

Both interview guides were drafted in English, piloted, and refined using a convenience sample of PLHIV and health workers at the clinic. The interview guide for PLHIV was then professionally translated to Luganda and checked for accuracy by members of the local study team who were bilingual.

All interviews including the informed consent were audio-recorded and transcribed verbatim. All Luganda transcripts were then translated to English for analysis. All transcripts were de-identified and stored in a secure digital folder accessible only by the research team.

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