GEO2R is considered as a useful interactive web tool for comparison and analysis of sample of multiple groups [21]. In present study, GEO2R tool was employed to explore the Differential Expressed Genes (DEGs) among controls and EMPD patients of GSE117285 dataset. Genes that satisfy the criteria of |log2 (fold change) | > 1.0 and adjusted P-value < 0.05 were distinguished as DEGs. Volcano plot was constructed using ggplot2 package of R, to visualize the significant and non-significant DEGs.

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