2.2. Determination of Meloxicam (MX) Solubility in Formulation Components
This protocol is extracted from research article:
Lyophilized Composite Loaded with Meloxicam-Peppermint oil Nanoemulsion for Periodontal Pain
Polymers (Basel), Jul 14, 2021; DOI: 10.3390/polym13142317

The solubility of MX was estimated in various oils, surfactants, and co-surfactants. Peppermint oil, oleic acid, soybean oil, Sefsol, palm kernel oil, coconut oil, and Labrafac Lipophile WL 1349 were studied as the oil phase. Meanwhile, Tween 80, Span 80, Labrasol, Triton, Cremophor, Kollifor, polyglyceryl oleate, and Plurol were analyzed as the surfactants. The co-surfactants included polyethylene glycol (PEG) 200, PEG 400, propylene glycol, Transcutol, glycerol, and ethanol. The solubility of MX was determined by shaking an excess of MX with 2 mL of each oil, surfactant, and co-surfactant samples at 25 ± 0.5 °C for 48 h. The samples were then centrifuged at 1200 rpm for 15 min, diluted with methanol, and quantified by UV-Vis spectrophotometry.

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