The mice (n = 90) were randomly divided into ten groups received saline (0.9% NaCl; 0.5 mL), R. adamsii leave extract obtained by the various solvent (0–100% methanol) at dose 50 mg/kg, and Rodiola rosea rhizome extract (5% rosavins, Vitaforest Ltd., Saint Petersburg, Russia; 50 mg/kg). In 60 min, the mice were individually placed in a glass cylinder (height 40 cm, diameter 20 cm) filled with water (height 15 cm; 22 ± 1 °C) and exhaustive swimming of rodents continued until the first immersion in the water. After the swimming sessions, the mice were towel-dried and returned to their housing. Each animal was used only once. The swimming time was measured using a stopwatch and was expressed in min. The experiment was realized in two versions, the first was the one-day application of plant extracts and the second was the 10-day application of plant extracts.

The mice (n = 54) were randomly divided into six groups received saline (0.9% NaCl; 0.5 mL), R. adamsii leave extract (January, May, July, October samples) at dose 50 mg/kg, and R. rosea extract (50 mg/kg) during 10 days and on the 10th day, the rodents were tested as described in Section 2.5.1. One hour later, the mice have been retested in the same conditions. The swimming times at each step were measured using a stopwatch and were expressed in min. At the end of the experiment, laboratory animals were decapitated and the homogenates of skeletal muscles (quadriceps femoris) and liver, and blood serum were assayed for the following biochemical parameters: skeletal muscles—adenosine triphosphate (fluorimetric ATP assay kit; Sigma-Aldrich, cat. No. MAK190), creatine phosphate (colorimetric phosphocreatine PCr ELISA kit; Abbexa Ltd., Cambridge, UK, cat. No. abx258965) and lactate (fluorimetric lactate assay kit; Sigma-Aldrich, cat. No. MAK064); blood serum—pyruvic acid (fluorimetric pyruvate assay kit; Sigma-Aldrich, cat. No. MAK071), glucose (colorimetric glucose assay kit; Sigma-Aldrich, cat. No. MAK264), malondialdehyde (colorimetric MDA assay kit; Abcam, Cambridge, UK, cat. No. ab238537), and catalase (catalase colorimetric activity kit; Invitrogen, Carlsbad, CA, USA, cat. No. EIACATC); liver—glycogen (colorimetric glycogen assay kit; Cayman Chemical, Ann Arbor, MI, USA, cat. No. 700480).

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