Data are expressed as mean ± standard error of mean (SEM). All statistical analyses were performed using GraphPad Prism 8.0 Software (La Jolla, CA, USA) and SPSS version 22.0 software (Abbott Laboratories, Chicago, IL, USA) through two-sided Student's t-test or one-way analysis of variance (ANOVA). Differences were considered statistically significant at P < 0.05.

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