All experiments were conducted according to the European Ethics Community Directive for the use of research animals (2010/63/EC). We followed the 3R principles to minimize the number of animals used, pain, and discomfort. The experimental protocol and procedures were approved by the local ethics committee for animal experimentation of Lyon 1 University (No. APAFIS#22363‐2019100915103240). Both experimental design and conduct of the study were performed strictly according to the ARRIVE guidelines. 23

Male, inbred CBA/Jrj mice were purchased from Janvier Labs, France with a certification as free of pathogenic viral, bacterial, and parasitic contaminants. Known to be susceptible to chronic infection by Tg, they were housed two per cage in our BSL2 animal facility (Hôpital de la Croix‐Rousse, Lyon, France). Room temperature was maintained at 22°C (+/‐ 2°C) with a 12 h light/dark cycle (light‐on at 7am). Animals were monitored every day and handled regularly for habituation.

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