The function of large myelinated sensory fibers in hind-paw skin was measured by recording sensitivity to light touch using manual von Frey filaments (range of 0.16 to 6.0 grams of force, Kom Kare, Inc.) as described in detail elsewhere (37). The testing filament sequence was used to calculate the 50% paw withdrawal threshold (in grams of force) for each hind paw exactly as described elsewhere (38).

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