We summarize demographics and baseline clinical characteristics using descriptive statistics; continuous data are summarized with number of mean or geometric mean (where noted) and standard deviation (SD). Categorical data are summarized using proportions.

We defined baseline eGFR for the study as the average of the 2 screening measurements and the day 1 eGFR measurement. For evaluation of the eGFR trajectory before trial participation, we obtained all eGFR values before trial participation going as far back as the eGFR value closest to 5 years but not >5.5 years and calculated the annualized eGFR slope (in mL/min/1.73 m2/year). We employed a longitudinal mixed model with the eGFR at each available time point as the dependent variable and time in years as the covariate. UACR results were log transformed for analysis and summarized using geometric means. In accordance with published guidance, we did not perform inference tests comparing baseline characteristics across groups.

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