The above data statistics were performed using SPSS 25.0 software and GraphPad Prism 8. Chi square test was used to compare the clinicopathological characteristics of TC/IC PD-L2 positive and negative patients and the clinical efficacy of the six cycle CHOP regimen. Fisher’s exact test was used to compare clinical outcomes between TC/IC PD-L2-positive and -negative patients who received six cycles of R-CHOP regimen. PFS was calculated from the day of diagnosis to the day of progression, relapse, or death. OS was calculated from the day of diagnosis to the day of death by any cause. Survival analysis was performed by log-rank test. Univariate and multivariate analyses were conducted using Cox proportional hazards regression model, and Omnibus test was used to verify the reliability of the model. The correlation between TC PD-L2 and M1 macrophage specific marker expression was tested by Pearson test. The difference was statistically significant at P < 0.05.

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