Under Ar atmosphere, compound b (358 mg, 2 mmol), 2,4-dimethylpyrrole (206 μL, 2.0 mmol), and POCl3 (188 μL, 2.0 mmol) were added into a 50 ml round bottom flask containing 20 ml DCM, and the mixture was stirred for 0.5 h at room temperature. Then, triethylamine (5 ml) was added dropwise. Then, boron fluoride etherate (5 ml) was added into the above mixture, which was stirred for another 12 h. Finally, the mixture was washed with saturated sodium chloride and extracted by DCM. The solvent was evaporated in vacuum, and the resulting crude product was purified by silica gel column chromatography (hexane/EtOAc 5:1) to obtain BOD as a dark red solid (395 mg, 65%). 1H-NMR (400 MHz, CDCl3) δ = 7.79 (d, J = 8.2, 1H), 7.75 (d, J = 8.2, 1H), 7.54 (t, J = 7.5, 1H), 7.34 (s, 1H), 6.05 (s, 1H), 2.57 (s, 1H), 2.30 (s, 1H). MS: [M] calcd. for C15H15BN2ClF2: 304.08; found 304.10.

Note: The content above has been extracted from a research article, so it may not display correctly.

Please log in to submit your questions online.
Your question will be posted on the Bio-101 website. We will send your questions to the authors of this protocol and Bio-protocol community members who are experienced with this method. you will be informed using the email address associated with your Bio-protocol account.

We use cookies on this site to enhance your user experience. By using our website, you are agreeing to allow the storage of cookies on your computer.