Preprocessing followed conventional procedures as implemented in FMRIB Software (FSL v6.0.1 http://www.fmrib.ox.ac.uk/fsl). This included motion correction, high-pass temporal filtering (100-s cut-off), and smoothing with a 5-mm full-width, half-maximum Gaussian kernel [41]. Functional and structural data were skull-stripped to remove non-brain tissue. Each subject’s functional images were registered to their MBW, followed by their MPRAGE using affine linear transformations, and then were normalized to the Montreal Neurological Institute (MNI) 152-brain-average template through nonlinear registration [42].

A whole-brain analysis of the ALC vs. BEV contrast was conducted across groups to confirm that the paradigm activated the expected mesocorticolimbic reward circuitry (see Supplement Fig. S1 and Table S1). The mean percent signal change between the ALC and BEV blocks was then extracted from an a priori defined region of interest: bilateral VS, 6-mm-radius sphere centered at ±12 6 9 in MNI space [26], which was then reverse-registered from standard space to each participant’s anatomical image.

Note: The content above has been extracted from a research article, so it may not display correctly.



Q&A
Please log in to submit your questions online.
Your question will be posted on the Bio-101 website. We will send your questions to the authors of this protocol and Bio-protocol community members who are experienced with this method. you will be informed using the email address associated with your Bio-protocol account.



We use cookies on this site to enhance your user experience. By using our website, you are agreeing to allow the storage of cookies on your computer.