Statistical analyses were performed using Prism 5.0 software. The immediate postoperative VAS was analyzed using the chi-square test. We used a linear mixed model with a Toeplitz covariance structure (smallest Akaike information criterion) for the analysis of repeated measures structure; an analysis of the primary and secondary endpoints of the full analysis set, which contained unbalanced data, was conducted. A p value < 0.05 was deemed statistically significant and p value < 0.001 was deemed statistically very significant.

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