The heart, liver, spleen, lung and kidney of the mouse were taken out and fixed in 10% neutral formalin for 48 h. After dehydration, they were embedded in paraffin according to standard methods to prepare tissue sections with a thickness of 5 μm. Hematoxylin and eosin (H&E) staining: H&E staining was performed according to standard methods [26], and histopathological changes were observed using Nikon TE2000 fluorescence microscope (Nikon, Japan).

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