All protocols involving animal experimentation were reviewed and approved by the respective Animal Care and Use Committee of each test facility. Study numbers for respective experiments were described in subsequent method sections of each assay. PK studies were performed at WuXiAppTec (Shanghai, China) Co., Ltd and adhered to the study protocol and Standard Operating Procedures (SOPs), but was not intended to be in full compliance with international good laboratory practice (GLP) regulations. All chemicals used were reagent grade or better.

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