The data was extracted manually by one reviewer (DL) from the publications into Microsoft Excel (version 2016) in pre-defined and labeled columns. General publication characteristics that were extracted, consisted of the country where the evaluation was performed, how the POCT was applied (disease and purpose), whether the POC test was evaluated in a primary care or secondary care setting, the specific setting (e.g., hospital or general practice), the purpose of the POC test (diagnosis, monitoring, or screening), the comparator, and the population. Furthermore, some methodological characteristics were also extracted, namely whether the evaluation was model- or trial-based, the type of health economic evaluation performed, the chosen time horizon, the perspective from which the costs and effects were evaluated, and the type of sensitivity analysis. Outcomes of interest extracted were the impact of POCT on costs (overall costs and cost per patient), the impact on health outcomes (e.g., quality-adjusted life-years [QALYs]/disability-adjusted life-years [DALYs], prescriptions avoided, life-years saved), and the balance between the two (e.g., incremental cost-effectiveness ratio). The conclusions of each evaluation were also extracted. The extracted data was summarized in both text and table format before providing a descriptive synthesis of findings.

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