The three independent datasets referred to purebred French Large White pigs produced in a divergent selection experiment for RFI. The selection program was described in full details elsewhere [49], including the equation to calculate RFI from a regression between observed feed intake and that expected based on requirements for maintenance (based on the metabolic BW) and performance (average daily gain, backfat thickness). From birth to weaning, all pigs were reared in the selection farm of INRAE (UE Genesi, Le Magneraud & Rouillé, France; 10.15454/1.5572415481185847E12). All pigs were weaned at 28 days (d), and were first fed ad libitum with standard starter and weaner diets. During subsequent test periods in dedicated buildings, pigs have undergone different feeding conditions depending on the experiments as described below. As indicated in the referenced publications [1921], the three experiments were conducted in accordance with the French legislation on animal experimentation, and the protocols were approved by regional ethical committees evaluating the research question, design, plan analysis, animal care and monitoring, and ways to minimize pain and consider limit points (especially regarding jugular blood sampling). At the end of each experiment, pigs were slaughtered using approved procedures, including electronarcosis followed by jugular exsanguination.

The first dataset [19] included 21 castrated males from the 7th generation of selection (n = 10 low RFI pigs and n = 11 high RFI pigs) housed at thermo-neutrality (24 °C) and reared at the INRAE experimental pig facility at Saint-Gilles, France (UE3P, 10.15454/1.5573932732039927E12). At 80 d of age, pigs were transferred in individual cages, and were fed a standard diet that met nutritional requirements for growth. At 87 d of age (59.2 kg BW on average), blood was collected from the jugular vein and prepared for RNA extraction. The feed conversion ratio (FCR) was calculated from individually measured daily feed intake and average daily gain for the 14 d of the trial (i.e., from 87 d to 100 d of age).

The second dataset [20] included 48 castrated males from the 8th generation of selection (n = 24 low RFI pigs and n = 24 high RFI pigs). Pigs were reared at the INRAE experimental pig facility at Saint-Gilles, France (UE3P, 10.15454/1.5573932732039927E12). At 74 d of age, pigs were transferred in individual cages and after 2 d of transition, the first half was fed a standard diet and the second half was fed a high-fiber high-fat diet during the growing and finishing phases. At 132 d of age (average BW of 75.6 kg), blood was sampled from the jugular vein and prepared for RNA extraction. The FCR was then calculated from 76 d to 132 d of age.

The third dataset [21] included 79 castrated males and females from the 9th generation of selection (n = 37 low RFI pigs and n = 42 high RFI pigs). Pigs were reared at the experimental INRAE pig facility at Le Magneraud, France (UE Genesi; 10.15454/1.5572415481185847E12). Blood was sampled at 40 d of age from the jugular vein. At 70 d of age, pigs were transferred to group-housing facilities equipped with single-place electronic feeders. The first half of the pigs were fed standard diets, whereas the second half was fed a high-fiber diet during the growing-finishing phases [21]. The FCR was then calculated from 90 d to 161 d of age.

In the three datasets, the reference to low or high RFI line was indicated for each pig, and the FCR value was individually attributed. Other factors (sex, season, generation, diet) were not taken into account.

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