Eighty paired LUAD and adjacent non-tumor tissue samples were obtained from patients undergoing operations in the Department of Thoracic Surgery, Jiangsu Cancer Hospital, from 2015 to 2018. None of the patients was previously treated with radiotherapy, chemotherapy, or immunotherapy. All LUAD tissues were confirmed by the histopathological reports. The study was approved by the ethics committee of Jiangsu Cancer Hospital, and written informed consent was obtained from all participants.

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