The present study reports on the events occurred in IDDVT and PDVT patients during their anticoagulant treatment. Follow-up was considered from inclusion of patients until December 2018, or until a permanent cessation of anticoagulant treatment, the last follow-up available in patients who subsequently were lost to follow-up or declined to further participate in the START-Register, or occurrence of major bleeding, thrombotic complications, death, whichever came first. During follow-up, detailed clinical reports of any relevant clinical outcome occurring in enrolled patients were collected. Major bleeding (MB), was defined according to International Society on Thrombosis and Haemostasis criteria. 9 Clinically relevant nonmajor bleeding (CRNMB) events were defined as any overt bleeding requiring a medical intervention and/or treatment discontinuation, not meeting any of the criteria for major bleeding. 10 Thromboembolic events were recorded and defined as verified events of either venous type (recurrent VTE episode, venous thrombosis in different sites, or superficial vein thrombosis) or arterial type (stroke/arterial thromboembolism/TIA or myocardial infarction).

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