Differences of the clinical characteristics between the responders and non-responders in cohort 1 were tested using the Wilcoxon rank-sum test for data not satisfying normal distribution (age, Tinetti, and TUG before and after CSF drainage), unpaired t test with unequal variance for Evan’s index and MMSE before and after CSF drainage, and chi-square test for gender. The Wilcoxon matched-pairs signed-rank test was used to compare the test scores before and after CSF drainage or shunt surgery in cohort 2. The statistical tests were performed in R.

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