Tumors were stratified into low-, intermediate-, and high-risk categories using American Urological Association tumor risk criteria.21,22 Intermediate-risk tumors were further stratified into 3 mutually nonexclusive subgroups: favorable intermediate risk, low-volume favorable intermediate risk, and unfavorable intermediate risk. Favorable intermediate risk was defined as tumors with 1 intermediate-risk factor (PSA level, 10-20 ng/mL [to convert to micrograms per liter, multiply by 1.0]; grade group 2; or clinical stage of T2b) and 50% or fewer positive biopsy cores. Unfavorable intermediate risk was defined as 2 or more intermediate-risk factors, 50% or more positive biopsy cores, or grade group 3 disease.23 Low-volume favorable intermediate risk was defined as tumors with 1 intermediate risk factor and 2 or fewer positive biopsy cores.

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