Animals (6 rats per condition) were treated during 21 consecutive days with Xanthurenic acid (XA; 100 mg/kg/day; dissolved in 1% bicarbonate solution). The drug was i.p injected in a 1 mL volume. The XA effect was compared to that of the neuroleptic haloperidol (0.5 mg/kg i.p in 1 mL) given daily for 21 days. Control animals were daily i.p injected with 1 mL of vehicle for the same period.

After the treatment schedule (i.e., on day 22) spontaneously firing dopaminergic neurons within the SN and the VTA nuclei were counted.

Note: The content above has been extracted from a research article, so it may not display correctly.

Please log in to submit your questions online.
Your question will be posted on the Bio-101 website. We will send your questions to the authors of this protocol and Bio-protocol community members who are experienced with this method. you will be informed using the email address associated with your Bio-protocol account.

We use cookies on this site to enhance your user experience. By using our website, you are agreeing to allow the storage of cookies on your computer.