Animals (6 rats per condition) were treated during 21 consecutive days with Xanthurenic acid (XA; 100 mg/kg/day; dissolved in 1% bicarbonate solution). The drug was i.p injected in a 1 mL volume. The XA effect was compared to that of the neuroleptic haloperidol (0.5 mg/kg i.p in 1 mL) given daily for 21 days. Control animals were daily i.p injected with 1 mL of vehicle for the same period.

After the treatment schedule (i.e., on day 22) spontaneously firing dopaminergic neurons within the SN and the VTA nuclei were counted.

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