The V7.0 miRTarBase,2 which is an online database containing plenty of experimentally validated microRNA–target interactions (Hsu et al., 2011), was applied to identify the potential target genes of the DE-miRNA. Species selects: Homo sapiens. miRNA ID was entered as “hsa-miR-590-3p/hsa-miR-492/hsa-miR-631” to obtain the gene list of predicted target genes. Since the list contains a small number of strong evidence genes, we selected all the genes in the gene list (including strong evidence and less strong evidence) for relevant pathway enrichment analysis.

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