Based on the above methods, we screened a gene signature, then ssGSEA was used to score the gene set. Based on these scores, we explored the prognostic value of gene signature in different melanoma cohorts and in different types of cancers. Meanwhile, in TCGA-SKCM, the prognostic significance of ssGSEA score of the gene signature was compared with the more classical gene sets at present. For instance, CYTOLYTIC score by Rooney et al (24), hallmark angiogenesis gene set and hallmark interferon gamma response gene set from the molecular signature database (25), immune response-related gene sets, CD4+T cell score and CD8+T cell score by CIBERSORT.

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