All statistical analyses were undertaken with R software (version 3.5.2, https://www.rproject.org), SPSS (version Windows 25, https://www.spss.com), and Medcalc (version 19.1.6, https://www.medcalc.org). For discrimination between MGMT methylated or MGMT unmethylated using visual radiographic features and clinical factors, the χ2 test was used to compare categorical variables, and an independent‐sample t test (conforming to a normal distribution)/Mann‐Whitney U test (not conforming to the normal distribution) was used to compare continuous variables (SPSS). The ROC analysis was carried out with Medcalc. Logistic regression, nomogram, calibration, and DCA were carried out with the glm, PredictABEL, and DecisionCurve packages of R software.

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